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The top two teams in the AL West collide when the Oakland Athletics take on the Houston Astros in the first game of a three-game series on Tuesday at RingCentral Coliseum in Oakland. The A's (25-17) own a half-game lead over the Astros (24-17), who have won six straight. Houston is a -111 money-line favorite in the latest Astros vs. A's odds from William Hill Sportsbook, while the A's are +101 underdogs. The over-under for total runs scored is eight. First pitch is set for 9:40 p.m. ET.

That is one of the marquee matchups among the 15 games on Tuesday's MLB schedule. Other games include the top two teams in the AL East -- the Boston Red Sox and Toronto Blue Jays -- beginning a three-game series in Dunedin, Fla., and Dodgers lefty Julio Urias looking for his sixth victory of the young season. Before you lock in your MLB picks on those games or any others Tuesday night, you need to see the MLB predictions and betting advice from the SportsLine Projection Model.

This model, which simulates every pitch of every game 10,000 times, had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line picks. It is off to a fast start in 2021, going 52-36 on top-rated MLB money-line picks through seven weeks, returning over $900. Anyone following it has seen huge rewards.

Now, the model has evaluated the latest MLB lines for Tuesday and posted its best bets for the evening games. Parlaying these four MLB picks would pay more than 13-1. Head to SportsLine to see the picks

Top MLB picks for Tuesday, May 18

The model likes the Mariners (-115) to beat the Tigers at 10:10 p.m. ET. The Mariners dropped the first game of the series against the Tigers on Monday, but Seattle is coming off three wins in four games against the Indians.

On Tuesday, the Mariners take on Detroit's Spencer Turnbull (2-2, 3.91 ERA), who has struggled on the road this season. In two starts away from Detroit this year, Turnbull has allowed eight runs and three walks in eight innings. By contrast Seattle starter Justin Dunn (1-1, 3.72) is much better pitching at home than on the road in his career, posting a 3.23 ERA at home versus 4.44 on the road. In addition, the Mariners are 7-1 in their last eight games at home against Detroit. 

How to make MLB predictions, parlays for Tuesday, May 18

The model has locked in three other MLB best bets, including one on a big underdog. You can see the best bets only at SportsLine.

So which MLB picks should you make on Tuesday for a shot at a big return of more than 13-1? And which surprising underdog do you need to be all over? Visit SportsLine now to see Tuesday's top MLB picks, all from the projection model off to a fast start in 2021, and find out.