The Toronto Blue Jays can overtake the Boston Red Sox in the AL East when the two teams meet on Wednesday in the second game of a three-game series at TD Ballpark in Dunedin, Fla. Toronto (23-17) trails Boston (25-18) by a half-game in the AL East, after shutting out the Red Sox 8-0 on Tuesday night behind seven strong innings from Hyun Jin Ryu. On Wednesday, Toronto is a -121 money-line favorite in the latest Blue Jays vs. Red Sox odds from William Hill Sportsbook, while Boston is a +110 underdog. First pitch is at 7:37 p.m. ET. 

That is one of the marquee matchups among the 15 games on Wednesday's MLB schedule. Other games include the top two teams in the AL West -- the Oakland Athletics and Houston Astros -- playing the second game of their three-game series and Cardinals starter Jack Flaherty facing the Pirates and looking to go 8-0 this season. Before you lock in your MLB picks on those games or any others Wednesday night, you need to see the MLB predictions and betting advice from the SportsLine Projection Model.

This model, which simulates every pitch of every game 10,000 times, had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line picks. It is off to a fast start in 2021, going 52-36 on top-rated MLB money-line picks through seven weeks, returning over $900. Anyone following it has seen huge rewards.

Now, the model has evaluated the latest MLB lines for Wednesday and posted its best bets for the evening games. Parlaying these four MLB picks would pay more than 13-1. Head to SportsLine to see the picks

Top MLB picks for Wednesday, May 19

The model likes the Red Sox (+110) to beat the Blue Jays at 7:37 p.m. ET. The Red Sox have one of the best offenses in the majors, ranking third in runs scored (217), batting average (.261) and OPS (.763). Prior to last night's loss to the Blue Jays, Boston had outscored its opponents, 26-10, in its last four games, going 3-1.

On Wednesday, the Red Sox will ride the arm of starter Garrett Richards (3-2, 3.89 ERA), who has been on a roll recently. Beginning April 27, the 32-year-old righty has allowed just six runs and 24 hits in 25 innings, going 3-0 with a 2.16 ERA and 1.16 WHIP. His last start arguably was his best, giving up zero runs and just five hits in six innings against the A's. In addition, Boston is 11-2 in its last 13 games when playing as the underdog. 

Featured Game | Toronto Blue Jays vs. Boston Red Sox

How to make MLB predictions, parlays for Wednesday, May 19

The model has locked in three other MLB best bets, including one on a big underdog. You can see the best bets only at SportsLine.

So which MLB picks should you make on Wednesday for a shot at a big return of more than 13-1? And which surprising underdog do you need to be all over? Visit SportsLine now to see Wednesday's top MLB picks, all from the projection model off to a fast start in 2021, and find out.