Cardinals starter Jack Flaherty looks to go 9-0 when he takes on the Chicago White Sox on Tuesday at Guaranteed Rate Field in Chicago. Flaherty (8-0, 2.53 ERA) leads the majors in wins and has won all but one of his starts this season. On Tuesday, he faces longtime friend and former high school teammate Lucas Giolito (3-4, 4.35). The White Sox are -135 money-line favorites in the latest White Sox vs. Cardinals odds from William Hill Sportsbook, while the Cardinals are +125 underdogs. First pitch is at 8:10 p.m. ET. 

That is one of the marquee matchups among the 15 games on Tuesday's MLB schedule. Other games include Corey Kluber of the Yankees making his first start since throwing a no-hitter and the Mets' Jacob deGrom (3-2, 0.68) returning to the mound after missing two starts due to right side tightness. Before you lock in your MLB picks on those games or any others Tuesday night, you need to see the MLB predictions and betting advice from the SportsLine Projection Model.

This model, which simulates every pitch of every game 10,000 times, had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line MLB picks. It is off to a fast start in 2021, going 61-44 on top-rated MLB money-line picks through eight weeks, returning well over $700. Anyone following it has seen huge rewards.

Now, the model has evaluated the latest MLB lines for Tuesday and posted its best bets for the evening games. Parlaying these four MLB picks would pay more than 12-1. Head to SportsLine to see the picks

Top MLB picks for Tuesday, May 25

The model likes the Red Sox (+101) to beat the Atlanta Braves at 7:10 p.m. ET. The Red Sox (29-19) have won four of their last five games but are coming off a 6-2 loss to the Phillies on Sunday. The Braves (23-24) also have won four of their last five and are on a three-game winning streak in which they outscored Pittsburgh 33-3.

Atlanta starts Charlie Morton (2-2, 4.60 ERA) on Tuesday, who has had a subpar season thus far. An All-Star in 2018 and '19, Morton has allowed 14 runs over his last four starts (16.2 innings), and the Braves have lost three of those games. The last time Morton faced Boston, in September, he allowed three runs on six hits in 4.1 innings in a 6-3 loss. In addition, the Red Sox have won six of their last seven meetings against an opponent from the National League. 

Featured Game | Boston Red Sox vs. Atlanta Braves

How to make MLB predictions, parlays for Tuesday, May 25

The model has locked in three other MLB best bets, including one on a big underdog. You can see the best bets only at SportsLine.

So which MLB picks should you make on Tuesday for a shot at a big return of more than 12-1? And which surprising underdog do you need to be all over? Visit SportsLine now to see Tuesday's top MLB picks, all from the projection model off to a fast start in 2021, and find out.