The top two teams in the National League West collide when the San Francisco Giants and San Diego Padres open a three-game series on Friday at Oracle Park in San Francisco. The Giants (18-13) lead the division and own the best record in the NL. The Padres (18-14) are in second place in the NL West and are tied for the second best record in the league. On Friday, the Padres are -135 money-line favorites in the latest Padres vs. Giants odds from William Hill Sportsbook, while the Giants are +125 underdogs. First pitch is set for 9:45 p.m. ET. 

That is one of the marquee matchups of 15 games on Friday's MLB schedule. Other games include the Indians hosting the Reds in a battle of Ohio, the AL West-leading A's hosting the Rays and the NL East-leading Phillies hitting the road to take on the Braves. Before making any MLB picks on those games or others in the evening, you need to see the MLB predictions and betting advice from the SportsLine Projection Model.

This model, which simulates every pitch of every game 10,000 times, had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line MLB picks. It is off to a profitable start in 2021, going 36-28 on top-rated MLB money-line picks through four weeks, returning almost $400. Anyone following it has seen huge rewards.

Now, the model has evaluated the latest MLB lines for Friday and posted its best bets for the evening games. Parlaying these four MLB picks would pay almost 22-1. Head to SportsLine to see the picks

Top MLB picks for Friday, May 7

One of the MLB picks the model loves for Friday: the model is high on Houston (-135) taking down the the Blue Jays in the first game of a three-game series at Minute Maid Park in Houston (8:10 p.m. ET). The Astros (16-15) are coming off a 7-4 win against the Yankees on Thursday at Yankee Stadium. Meanwhile, the Blue Jays (15-14) enter the series off a 10-4 victory at Oakland.

On Friday Houston will face struggling Toronto starter Ross Stripling (0-1, 6.39 ERA). The 31-year-old righty has given up nine runs and 18 hits in 12.2 innings this season. He is making just his second start since returning from the injured list because of forearm tightness.

Featured Game | Houston Astros vs. Toronto Blue Jays

How to make MLB predictions, parlays for Friday, May 7

The model has locked in three other MLB best bets, including one on a surprising underdog. You can see the best bets only at SportsLine.

So which MLB picks should you make on Friday for a shot at a big return of almost 22-1? And which surprising underdog do you need to be all over? Visit SportsLine now to see Friday's MLB picks, all from the projection model off to a fast start in 2021, and find out.