The Houston Astros will look to even the series when they take on the Boston Red Sox in Game 4 of their 201 American League Championship Series on Tuesday. The Astros (95-67), who won the AL West Division, have been outscored 25-13 in the series. The Red Sox (90-72), who took second in the AL East, have been red hot this postseason. After taking out the New York Yankees in the Wild Card Game, the Red Sox outlasted the top-seeded Tampa Bay Rays three games to one in the ALDS. After losing Game 1 in Houston, Boston has won the last two games, including a 12-3 triumph on Monday. The starting pitching matchup is Zack Greinke for Houston vs. Nick Pivetta for Boston.

The game is slated to begin at 8:08 p.m. ET from Fenway Park. Boston is a -125 favorite (risk $125 to win $100) on the money line in the latest Astros vs. Red Sox odds from Caesars Sportsbook, while the over-under for total runs scored is 10. Before making any Astros vs. Red Sox picks, be sure to see the 2021 MLB playoff predictions and betting advice from SportsLine's proven computer model

This model, which simulates every game 10,000 times, enters the third week of the 2021 MLB playoffs with a 207-176 record on top-rated MLB money-line picks, returning well over $600. Anyone following it has seen some huge returns.

Now, the model has dialed in on Red Sox vs. Astros and just released its coveted 2021 ALCS picks and predictions. You can visit SportsLine now to see the model's ALCS picks. Here are the MLB odds and betting lines for Astros vs. Red Sox:

  • Astros vs. Red Sox money line: Houston +115, Boston -125
  • Astros vs. Red Sox run line: Boston -1.5 (+145)
  • Astros vs. Red Sox over-under: 10 runs
  • HOU: The Astros are 4-1 in their last five games after allowing five runs or more in their previous game
  • BOS: The Red Sox are 7-0 in their last six postseason home games
Featured Game | Boston Red Sox vs. Houston Astros

Why you should back the Red Sox

Center fielder Kike Hernandez was 2-for-4 in Monday's win and is batting .615 in the series. He has a six-game hitting streak, going 17-for-29 (.586) with four doubles, five homers and nine RBIs during that stretch. He was 4-for-5 with a double and two home runs in Game 1. In nine games this season against Houston, he is batting .371 with four doubles, three homers and six RBIs.

Third baseman Christian Arroyo has also come up big when needed. He cracked a two-run homer in the bottom of the third inning in Game 3 to give Boston an insurmountable 9-0 lead en route to the nine-run win on Monday. He has hits in all three games and is batting .273 in the series. He was key in the ALDS series win over Tampa Bay, going 3-for-5 with a double in Game 3 of that series.

Why you should back the Astros 

Outfielder Kyle Tucker provided Houston's offense in Game 3 with a fourth-inning three-run home run. He is hitting .300 for the series, including a 2-for-4 performance in Game 2. He is 8-for-27 (.296) with two doubles, three homers and 11 RBIs this postseason. For the season, Tucker hit .294 with 30 homers, 92 RBIs and 83 runs scored. In nine career games against Boston, Tucker is 15-for-35 (.429) with seven doubles, one homer and 11 RBIs.

First baseman Yuli Gurriel has been red hot in the series, going 5-for-10 with a homer and three RBIs. He was 2-for-3 in Game 3 and has a four-game hitting streak this postseason. He has hit Boston hard this season, going 14-for-31 (.452) with a double, three home runs and nine RBIs in nine games. During the regular season, Gurriel batted .319 with 15 homers, 81 RBIs and 83 runs scored.

How to make Red Sox vs. Astros ALCS picks

The model is leaning over on the total, projecting 10.5 combined runs. It also says one side of the money line has all the value. Head to SportsLine now to see its MLB picks

So who wins Game 4 of Astros vs. Red Sox in the ALCS 2021? And which side of the money line has all the value? Visit SpotsLine now to see which side to jump on, all from the model that has crushed its MLB picks, and find out.