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The Houston Astros will look to win two games in a row to take a commanding 3-2 lead when they take on the Boston Red Sox in an American League Championship Series Game 5 showdown on Wednesday. Both teams have taken turns busting out on offense and it was Houston's turn on Tuesday when the Astros (95-67) scored seven runs in the ninth inning of a 9-2 triumph to even the series. The Red Sox (92-70), who have outscored the Astros 27-22 in the series, are 6-0 in the postseason when scoring six runs or more. Houston is 5-2 in the playoffs when scoring five or more runs.

First pitch from Fenway Park is set for 5:08 p.m. ET. The Red Sox and Astros are two of the top three hitting teams in the postseason. Boston has an MLB-high .300 team batting average and .544 slugging percentage, while Houston is hitting .277 with a .438 slugging percentage. The Red Sox are a -125 favorite (risk $125 to win $100) on the money line in the latest Astros vs. Red Sox odds from Caesars Sportsbook, while the over-under for total runs scored is 9.5. Before making any Red Sox vs. Astros picks, be sure to see the 2021 MLB playoff predictions and betting advice from SportsLine's proven computer model

This model, which simulates every game 10,000 times, enters the third week of the 2021 MLB playoffs with a 207-176 record on top-rated MLB money-line picks, returning well over $600. Anyone following it has seen some huge returns.

Now, the model has dialed in on Red Sox vs. Astros and just released its coveted 2021 ALCS picks and predictions. You can visit SportsLine now to see the model's ALCS picks. Here are the MLB odds and betting lines for Astros vs. Red Sox:

  • Astros vs. Red Sox money line: Houston +115, Boston -125
  • Astros vs. Red Sox run line: Boston -1.5 (+145)
  • Astros vs. Red Sox over-under: 9.5 runs
  • HOU: The Astros are 11-5 in their last 16 playoff games as an underdog
  • BOS: The Red Sox are 6-1 in their last seven postseason games as a favorite
Featured Game | Boston Red Sox vs. Houston Astros

Why you should back the Red Sox

Center fielder Enrique Hernandez has been on fire in the series and is hitting .500. He was 1-for-5 in Tuesday's loss and has a seven-game hitting streak, with five multi-hit games. In nine postseason games, Hernandez is hitting 19-for-41 (.463) with four doubles, five homers and nine RBIs. He was 4-for-5 with a double and two home runs in Game 1. In 10 games this season against Houston, he is batting .350 with four doubles, three homers and six RBIs.

Infielder Christian Arroyo has been a spark for the Red Sox during the postseason. He hit a two-run homer in the bottom of the third inning in Game 3 of Boston's 12-3 victory on Monday, and has hits in all four games. He is batting .286 with a triple, home run and three RBIs in the series. 

Why you should back the Astros 

Outfielder Michael Brantley has been dominant this postseason with hits in seven of eight games, including three multi-hit performances. He helped fuel the Astros' seven-run ninth inning on Tuesday and was 2-for-5 with a double, three RBIs and one run scored. He finished the regular season with a .311 batting average with eight homers, 47 RBIs and 68 runs scored. Brantley has pounded Boston pitching throughout his career and is batting .319 against the Red Sox in 55 games, including 18 doubles, three homers and 27 RBIs.

First baseman Yuli Gurriel has been seeing the ball well in this series, going 6-for-14 (.429) with a homer and three RBIs. He has hit Boston hard this season, going 15-for-35 (.429) with a double, three home runs and nine RBIs in 10 games. He was 2-for-3 in Game 3 and has a five-game hitting streak this postseason. During the regular season, Gurriel batted .319 with 15 homers, 81 RBIs and 83 runs scored.

How to make Astros vs. Red Sox ALCS picks

The model is leaning over on the total, projecting 10.2 combined runs. It also says one side of the money line has all the value. Head to SportsLine now to see its MLB picks

So who wins Game 5 of Astros vs. Red Sox in the ALCS 2021? And which side of the money line has all the value? Visit SpotsLine now to see which side to jump on, all from the model that has crushed its MLB picks, and find out.