The Boston Red Sox will try to force a deciding Game 7 when they square off against the Houston Astros in Game 6 of the 2021 ALCS on Friday at Minute Maid Park in Houston. Once up 2-1 in the series, the Red Sox have dropped the last two games to put them on the brink of elimination. On Friday Nathan Eovaldi (1-1, 10.50 ERA), who grew up in the Houston area, will take the mound for Boston. He will face Astros rookie Luis Garcia (0-1, 24.55).

First pitch is set for 8:08 p.m. ET. Houston is the -111 favorite (risk $111 to win $100) in the latest Astros vs. Red Sox odds from Caesars Sportsbook while Boston is a +101 underdog. The over-under for total runs scored is nine. Before making any Red Sox vs. Astros picks, make sure to check out the latest MLB playoff predictions and betting advice from the SportsLine Projection Model.

This model, which simulates every game 10,000 times, enters the third week of the 2021 MLB playoffs with a 207-176 record on top-rated MLB money-line picks, returning well over $600. Anyone following it has seen some huge returns.

Now, the model has dialed in on Astros vs. Red Sox and just revealed its coveted picks and predictions. You can visit SportsLine now to see the model's MLB picks. Here are the MLB lines and trends for Red Sox vs. Astros:

  • Astros vs. Red Sox money line: Houston -111, Boston +101
  • Astros vs. Red Sox run line: Houston -1.5 (+170) 
  • Astros vs. Red Sox over-under: 9 runs 
  • HOU: Kyle Tucker is tied for the MLB lead in RBI in the playoffs (12) 
  • BOS: Kike Hernandez leads all MLB players in the postseason in hits (19)
Featured Game | Houston Astros vs. Boston Red Sox

Why you should back the Astros

Houston has arguably the deepest lineup in baseball. Jose Altuve, the 2017 MVP, leads off. Michael Brantley, who finished second in the AL in batting average (.311), bats second. Alex Bregman, the 2019 AL MVP runner-up, hits third. Yordan Alvarez, who had 33 home runs and 104 RBI, is in the cleanup spot. He is followed by the clutch Carlos Correa, the surging Kyle Tucker and AL batting champion Yuli Gurriel in the seven hole.

In addition, the Astros pitchers have done a good job against the Red Sox bats in the last two games. In Games 4 and 5 -- both Boston losses -- the Red Sox hit a combined .131 and scored three runs on eight hits. All three runs came on home runs.

Why you should back the Red Sox

Boston already rocked Garcia earlier in this series. In Game 2, the Red Sox clobbered Garcia for five runs and two hits, including a grand slam, and three walks in just one inning of work. He left that game with right knee discomfort, which puts his possible effectiveness in Game 6 in question. In two postseason starts this season, he has a 24.55 ERA. 

In addition, Kike Hernandez has been on fire in the postseason. In his last eight games, the Boston centerfielder is batting .474, slugging .974 and has an OPS of 1.449. He has five home runs, nine RBI and eight runs scored during that stretch.

How to make Astros vs. Red Sox picks

SportsLine's model is leaning over on the run total, projecting a combined 10.7 runs. It also says one side of the money line has all the value. You can only see the model's Red Sox vs. Astros pick at SportsLine

So who wins Game 6 of the ALCS and Astros vs. Red Sox? And which side of the money line has all the value? Visit SportsLine now to see which side of the money line to jump on, all from the advanced model that has a 207-176 record on top-rated MLB money line picks, and find out.