MLB: Los Angeles Dodgers at Atlanta Braves

The Seattle Mariners try to stay red hot and the New York Yankees seek to maintain their dominance of their AL East rivals as part of Friday's 15-game MLB schedule. The Mariners have won five straight and eight of their last nine, including an 8-3 victory against the Blue Jays on Thursday. They face off again Friday in Seattle at 10:10 p.m. ET. Meanwhile, the Yankees took a 6-5 victory against the Red Sox in their series opener Thursday, New York's ninth win in its past 11 against Boston. Now they are set to start left-hander Nestor Cortes (7-3, 2.44 ERA) against Red Sox righty Connor Seabold (0-1, 8.31 ERA) as Boston battles major injury issues in their rotation.

First pitch for the Yankees vs. Red Sox game is set for 7:10 p.m. ET. Caesars Sportsbook lists New York as a -160 favorite in its latest Red Sox vs. Yankees odds, with Boston the +135 underdog. There are tons of opportunities for wagers on this full MLB schedule, and there is value if you really dig into the matchups. If you combine your favorite picks into a parlay, you can cash in huge. Before you make any MLB picks or parlays, be sure to check out the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it is 271-232 on top-rated MLB money-line picks since the start of the 2021 season, returning well over $500 for $100 players. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen profitable returns. 

Now, the model has locked in four confident MLB best bets for Friday. The parlay doesn't start until 8:10 p.m. ET, giving you plenty of time to make your MLB picks. If you successfully parlay the picks, you'd be looking at a payout of well over 16-1. You can see the model's MLB picks for Friday only at SportsLine. 

Top MLB picks today

SportsLine Projection Model is really high on the Brewers (-225) to beat the Pirates (8:10 p.m. ET), with Milwaukee winning in well over 70 percent of simulations. The Brewers have won eight of the 10 matchups this year, and the Pittsburgh bullpen, which wasn't very good to begin with, is going to be gassed. Pittsburgh is 29th in MLB in bullpen ERA (4.78) and 28th in WHIP (1.41), and the relievers allowed 12 runs in three innings against the Yankees on Wednesday night.

The Pirates then played a doubleheader Thursday, splitting with the Reds, before traveling to Milwaukee. JT Brubaker (2-7, 4.28 ERA) is expected to start for the Pirates opposite Aaron Ashby (1-6, 4.60), so this could be a slugfest. That gives the Brewers the advantage, as they score almost a full run more per game (4.6-3.7) and are fourth in MLB in home runs. Rowdy Tellez (17 homers) and Willy Adames (16) have been mashing and could go off Friday night.

Featured Game | Milwaukee Brewers vs. Pittsburgh Pirates

How to make Friday MLB parlays

The model has locked in three other best bets for Friday, all of them underdogs that can help you to a massive payday. You can only see the model's MLB parlay picks and best bets for Friday at SportsLine.

Which MLB picks should you target for Friday in a parlay offering a payout of more than 16-1? And which underdogs with excellent value are must-backs? Visit SportsLine now to see the MLB best bets for Friday from the model that is 271-232 on top-rated MLB money-line picks since the start of the 2021 season.