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The 2022 MLB season continues on Saturday, and one of the marquee games on the schedule will be Red Sox vs. Cardinals at 7:15 p.m. ET as both teams are in the thick of the MLB playoff hunt. St. Louis is currently first in the NL Central while Boston is fourth in the AL East, but with a 35-30 record the Red Sox are only a half-game out of the final AL Wild Card spot. The Red Sox survived a four-run ninth inning from the Cardinals to win Game 1 of the series 6-5 on Friday night and will send Kutter Crawford to the mound to take on Dakota Hudson on Saturday.

Boston is the -120 (risk $120 to win $100) home favorite in the latest MLB odds from Caesars Sportsbook and the over-under for total runs is at 10. It's one of two games on the Saturday MLB schedule with a total listed in double-digits, and it will be interesting to see if these two offenses can stay hot against a couple of back-of-the-rotation pitchers. Before locking in any MLB picks or parlays, be sure to check out the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a strong start to the 2022 season. It's on a 55-42 roll on top-rated MLB money-line picks through 10 weeks, returning over $600 for $100 players. Anyone following it has seen huge returns.

Now, the model has locked in three confident MLB best bets for Saturday. They all involve games at 7:15 p.m. ET or later, so there's still time to get these MLB picks in. If you successfully parlay the picks, you'd be looking at a payout of almost 7-1. You can see the model's MLB picks for Saturday only at SportsLine. 

Top MLB picks today

One of the MLB picks the model likes for Saturday: San Diego (-120) beats Colorado (see tickets at StubHub). These division rivals split a four-game series last weekend and the Rockies won Game 1 of the series 10-4, which has helped created some value on the side of the NL West leaders. San Diego has a half-game lead over the Dodgers in the division and is 11-6 with a 45-run differential in the month of June.

The Padres have a 3.43 team ERA on the season that ranks second in the National League and Nick Martinez is scheduled to take the bump on Saturday. After four seasons in Japan, the 31-year-old has been a pleasant surprise for the Padres with a 3.74 ERA and 56 strikeouts over 55 2/3 innings. The model expects Martinez to continue pitching well and has San Diego winning in nearly 60 percent of simulations.

Featured Game | Colorado Rockies vs. San Diego Padres

How to make MLB parlays for Saturday

The model also has locked in three other best bets for Saturday, including a pair of underdogs who provide strong value. You can only see the model's MLB parlay picks and best bets for Saturday at SportsLine.

What MLB picks should you target for a parlay offering a payout of almost 7-1? And which underdogs with excellent value are must-backs? Visit SportsLine now to see the MLB best bets for Saturday from the model on a 55-42 roll on top-rated MLB money-line picks, and find out.