Two-way star Shohei Ohtani takes the mound for one last time when he and the Los Angeles Angels (73-88) square off against the Oakland Athletics (59-102) on the final day of the 2022 regular season. Ohtani, who agreed last week to a $30 million contract with the Angels for the 2023 season, has had another MVP-caliber season, hitting .273 with 34 homers, 95 RBI and a .877 OPS. On the mound he is 15-8 with a 2.35 ERA and 213 strikeouts. Los Angeles is a -225 favorite in the latest Angels vs. Athletics odds from Caesars Sportsbook, while Oakland is a +185 underdog. The over/under for runs scored is 6.5.

First pitch is set for 4 p.m. ET from Oakland Coliseum. The game is one of 16 on the MLB schedule for Wednesday. Elsewhere in the majors, Toronto takes an MLB-best four-game winning streak into a doubleheader against Baltimore, and the Dodgers' Clayton Kershaw makes his final regular season start, against the Rockies. Before making any MLB picks or parlays, be sure to see the predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it enters the penultimate week of the regular season on a 14-3 run on top-rated money-line picks, returning almost $900 for $100 players. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen huge returns.

Now, the model has locked in four confident MLB best bets for Wednesday. They all involve games at 4 p.m. ET or later, so there's still time to get these MLB picks in. If you successfully parlay the picks, you'd be looking at a payout of 14-1. You can only see the model's MLB picks at SportsLine

Top MLB picks today

The model, which ran 10,000 simulations on each of Wednesday's games, likes the New York Yankees (-110) to knock off Texas. The Yankees (99-62) have clinched the No. 2 seed in the American League playoffs and need to stay sharp since they won't play their first playoff game until Tuesday. Meanwhile, the Rangers (67-94) have missed the playoffs for the sixth straight season.

New York has one of the best lineups in the majors. The Yankees rank in the top five in baseball in homers (first, 253), runs (second, 805), OPS (fourth, .752), slugging (fourth, .427) and on-base percentage (fifth, .325). On Wednesday, they face a Texas starter, Glenn Otto, who struggled in six September starts, going 0-2 with a 4.50 ERA and allowing seven homers in 30 innings. See who else to back right here.

Featured Game | Texas Rangers vs. New York Yankees

How to make MLB picks and parlays for Wednesday

The model also locked in three other best bets for Wednesday, including a play on a big AL underdog. You can see the model's MLB Wednesday best bets and parlay only at SportsLine.

What MLB picks should you target for a payout of 14-1? And what big AL underdog does the model like on Wednesday? Visit SportsLine now to see the MLB best bets from an advanced model that is on a 14-3 run on top-rated money-line picks