All 30 MLB teams are scheduled to be in action on Friday, with the MLB schedule beginning at 6:35 p.m. ET. The latest MLB odds from Caesars Sportsbook show some heavy favorites on the board. The New York Mets are -240 (risk $240 to win $100) on the money line against the Seattle Mariners in a 7:10 p.m. ET start. The Los Angeles Dodgers, meanwhile, are -220 against the Phillies in a 10:10 p.m. ET first pitch.

Other MLB lines of note for Friday include the New York Yankees at -185 against the White Sox, while the red-hot Houston Astros are -150 against the Washington Nationals. With such a large slate and lines of different sizes, there are plenty of ways to attack your MLB best bets. Before making any MLB picks or parlays, be sure to check out the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times and is off to a sizzling start to the 2022 season. It's on a 31-19 roll on top-rated MLB money-line picks through five weeks, returning almost $800 for $100 players. Anyone following it has seen huge returns.

Now, the model has locked in four confident MLB best bets for Friday. All the games occur at 7:10 p.m. ET or later, so there's still plenty of time to make these MLB picks. If you successfully parlay the picks, you'd be looking at a payout of over 25-1. You can only see the model's MLB picks at SportsLine.

Top MLB picks today

The model, which simulated every game on Friday's schedule 10,000 times, is going over 7.5 (-125) in the Yankees vs. White Sox matchup at 8:10 p.m. ET. 

The Yankees enter this game with the No. 5 scoring offense in Major League Baseball, averaging 4.84 runs per game. The White Sox, meanwhile, have struggled offensively to start the season with an average of 3.63 runs per game. But they still have a lot of big bats in the lineup like Tim Anderson, Jose Abreu and Luis Robert who can help them pile up runs quickly on any given night. 

The total being set at 7.5 has led to consistent overs for both teams this year as they're a combined 13-7 to the over in this situation. SportsLine's model is projecting an average of 8.3 runs in the simulations, helping clear this total in well over 50 percent of simulations. 

Featured Game | Chicago White Sox vs. New York Yankees

How to make MLB picks and parlays for Friday

The model also locked in three other MLB best bets for Friday, including a strong play on an underdog who wins outright well over 60 percent of the time. You can only see the model's Friday MLB best bets and parlay at SportsLine.

What MLB picks should you target for a payout of over 25-1? And which underdog is the model all over on Friday? Visit SportsLine now to see the MLB best bets from an advanced model that is on a 28-13 roll on top-rated MLB money-line picks through four weeks, and find out.