The Seattle Mariners play the franchise's first playoff game since the 2001 season when they take on the Toronto Blue Jays in Game 1 of their American League Wild Card Series on Friday. The Mariners (90-72) finished second in the AL West, which was good enough to earn the second wild card spot and end the longest playoff drought in North America's four major pro sports leagues. Toronto (92-70) is a -135 favorite in the latest MLB odds from Caesars Sportsbook, while Seattle is a +115 underdog. The Over/Under for runs scored is 7.

First pitch is at 4:07 p.m. ET at the Rogers Centre in Toronto. Elsewhere on Friday in the 2022 MLB playoffs, the Guardians host the Rays, the Mets welcome the Padres, and the Phillies visit the Cardinals. Each series is a best-of-three, with the winners advancing to the divisional round. Before making any MLB picks or parlays, be sure to see the predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it entered the final week of the regular season on an 18-8 run on top-rated money-line MLB picks, returning almost $700 for $100 players. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen huge returns.

Now, the model has locked in four confident MLB best bets for Friday. If you successfully parlay the picks, you'd be looking at a payout of well over 10-1. You can only see the model's MLB picks at SportsLine

Top MLB playoff picks for Friday

The model, which ran 10,000 simulations on each of Friday's wild card games, likes Cleveland to knock off Tampa Bay and take a 1-0 series lead. The Guardians (92-70) ended the regular season on a roll, going 24-6 since Sept. 30. They won four of the six meetings against the Rays (86-76) during the regular season.

One of the reasons for Cleveland's success down the stretch was starter Shane Bieber (13-8, 2.88 ERA). The 27-year-old righty hasn't lost since Sept. 1 and is 5-0 over his last six starts. He will be supported by one of the best bullpens in baseball. During the regular season, Guardians relievers ranked fifth in the majors in ERA (3.05) and third in WHIP (1.11). See who else to back right here.

Featured Game | Cleveland Guardians vs. Tampa Bay Rays

How to make MLB picks and parlays for Friday

The model also locked in three other best bets for Friday, including a play that would pay plus-money. You can see the model's MLB best bets and parlay only at SportsLine.

What MLB picks should you target for a payout of well over 10-1? And what wager that pays plus-money does the model like on Friday? Visit SportsLine now to see the MLB best bets from an advanced model that is on an 18-8 run on top-rated money-line picks.