The 2022 World Series between the Houston Astros and Philadelphia Phillies continues with Game 5 on Thursday. Though the stakes are rising as the Fall Classic, which is tied 2-2, progresses, it'll be nearly impossible to match Game 4's historic value. The Astros threw a combined no-hitter on Wednesday, marking just the second time one has been thrown in a World Series game, with the last one coming in the form of Don Larsen's perfect game in 1956. Coming off that dominant performance, the Astros will flip their rotation to the top and send Justin Verlander (1-0, 7.20 ERA in playoffs) to the hill as they try to take a 3-2 series lead back to Houston. The Phillies will start Noah Syndergaard (0-0, 1.69 ERA).

First pitch at Citizens Bank Park in Philadelphia is set for 8:03 p.m. ET. Caesars Sportsbook lists Houston as the -160 favorite (risk $160 to win $100) on the money line in the last Astros vs. Phillies odds. Philadelphia is the +135 underdog and the over/under for total runs is set at 7.5. Before locking in any Phillies vs. Astros picks, be sure to see the 2022 World Series predictions from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it entered the 2022 World Series on a 20-13 roll on top-rated MLB money-line picks, returning more than $400. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen huge returns.

Now, the model has dialed in on Astros vs. Phillies and just revealed its coveted World Series 2022 picks and predictions. You can visit SportsLine now to see the model's MLB picks. Here are the MLB odds and World Series betting lines for Phillies vs. Astros:

  • Astros vs. Phillies money line: Houston -160, Philadelphia +135
  • Astros vs. Phillies over/under: 7.5 runs
  • Astros vs. Phillies run line: Houston -1.5 (+110)
  • HOU: The Astros are 40-12 in their last 52 Thursday games
  • PHI: The Phillies are 5-2 in their last seven playoff games
  • Astros vs. Phillies picks: See picks at SportsLine

Why you should back the Astros

Houston has its ace on the mound as Verlander will make his second start of the series. He lost Game 1 and hasn't been as dominant overall in the postseason, but he had an 18-4 record in the regular season with a league-best 1.75 ERA and WHIP of 0.83. First baseman Yuli Gurriel had a hot bat on Wednesday night, going 2-for-4 with an RBI and one stolen base. Gurriel has five hits in the series and is batting .313 against the Phillies. He has hits in nine of 11 playoff games in 2022. He hit .242 during the regular season with eight homers, 53 RBIs and 53 runs scored.

Also powering the Houston offense is left fielder Kyle Tucker. Tucker doubled in a run in Wednesday's win and is hitting .286 with two homers and five RBIs in the series. Tucker was one of the Astros' top hitters this season, batting .257 with 30 homers, 107 RBI and 71 runs scored. He is a career .275 hitter against right-handed pitchers.

Why you should back the Phillies

It's easy to be down on the Philadelphia offense after it went hitless in Game 4. But just one night earlier this lineup tied a World Series record with five home runs in the Game 3 win, so this offense can get geared up in a hurry. Bryce Harper has been the most complete hitter for the Phillies in the 2022 MLB playoffs, hitting .368 with an OPS of 1.199. He's hit six home runs and recorded 13 RBI. Rhys Hoskins has provided almost identical power numbers, going deep six times and driving in a dozen runs.

Verlander always presents a challenge, but he's been human in the postseason. The Phillies beat him in Game 1 when he gave up five earned runs in as many inning pitched. He pitched well against the Yankees in the ALCS, but he was tagged for six earned runs in four innings in the ALDS against the Mariners, so Philadelphia should have confidence that it can get back to denting the scoreboard on Thursday. 

How to make Phillies vs. Astros picks

SportsLine's model is leaning Over on the total, projecting 7.8 combined runs. It also says one side of the money line has all the value. You can only get the model's World Series Game 5 pick at SportsLine

So who wins Astros vs. Phillies World Series Game 5? And which side of the money line has all the value? Visit SportsLine now to see which side of the Phillies vs. Astros money line to jump on, all from the advanced model that is on a 20-13 roll on top-rated MLB money-line picks, and find out.