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The St. Louis Cardinals will look for the series sweep when they take on the Cleveland Indians in an interleague matchup on Wednesday. The Cardinals (51-50) defeated the Indians (49-49) 4-2 on Tuesday. St. Louis, third in the National League Central, has won two in a row and seven of 10. Cleveland, second in the American League Central, has lost four of five on its six-game homestand.  

First pitch is set for 1:10 p.m. ET from Progressive Field in Cleveland. The Indians lead the all-time series 19-13, including a 7-5 edge in games played at Cleveland. The Cardinals are a -111 favorite on the money line in the latest Cardinals vs. Indians odds from William Hill Sportsbook, while the over-under for total runs scored is nine. Before making any Indians vs. Cardinals picks, be sure to see the MLB predictions and betting advice from SportsLine's proven model

This model, which simulates every pitch of every game 10,000 times, is a profitable 132-109 on top-rated money-line MLB picks through 17 weeks in the 2021 season. It also had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line picks. Anyone following it has seen some huge returns.

Now, the model has dialed in on Cardinals vs. Indians. You can visit SportsLine now to see its MLB picks. Here are the MLB odds today and betting trends for Indians vs. Cardinals:

  • Cardinals vs. Indians money line: Cleveland +101, St. Louis -111
  • Cardinals vs. Indians run line: Cleveland -1.5 (+175)
  • Cardinals vs. Indians over-under: 9 runs
  • STL: The Cardinals are 7-13 in their last 20 games on the road
  • CLE: The Indians are 4-2 in their last six interleague home games
Featured Game | Cleveland Indians vs. St. Louis Cardinals

Why you should back the Indians

Cleveland is expected to send right hander Zach Plesac (5-3, 4.30 ERA) to the mound. He has won his last four decisions. He is coming off a no-decision in his last start, a 10-5 Cleveland loss to Tampa Bay. Plesac allowed four earned runs on eight hits in 6 2/3 innings. He walked two and struck out three. For the season, he has walked 15 batters, while striking out 48. He has yet to face St. Louis.

Offensively, shortstop Amed Rosario has been red hot and has a four-game hitting streak. During that span, he is 5-for-16 (.313). He also has hits in nine of his last 11 games, including a 3-for-5 performance at Houston on July 19. In 16 career games against the Cardinals, he is batting .241 with two triples and six RBIs.

Why you should back the Cardinals 

St. Louis is scheduled to start left-hander Kwang Hyun Kim (6-5, 2.88 ERA). Kim has been on a roll, winning his last five starts. In his last outing on July 22 against the Chicago Cubs, he allowed just two earned runs on two hits in six innings. He walked one and struck out seven. For the season, he has walked 28 and struck out 67 and has a 1.17 WHIP. This will be his first time facing the Indians.

First baseman Paul Goldschmidt has raised his batting average 18 points since the start of the month and is hitting .270. He also has homered 17 times with 55 RBIs and 54 runs scored. Since July 1, Goldschmidt has eight multi-hit games, including a 3-for-4 performance against the San Francisco Giants on July 17. He homered in that game and drove in a pair of runs. In 11 career appearances against Cleveland, he is hitting .250 with five doubles, one home run and four RBIs. He has also walked six times and stole two bases.

How to make Indians vs. Cardinals picks

SportsLine's model is leaning under on the total, as the teams combine for 8.3 runs in the simulations, and it also says one side of the money line has all the value. You can only see the model's MLB picks at SportsLine.

So who wins Cardinals vs. Indians? And which side of the money line has all the value? Visit SportsLine now to see which side of the money line to jump on, all from the advanced model that has crushed its MLB picks, and find out.