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The Cincinnati Reds will host the Chicago Cubs in a battle between division rivals on Tuesday. Cincinnati and Chicago face off in the second game of a four-game series in late May, with Great American Ball Park serving as the venue. The Reds are 12-29 this season after a 7-4 loss to the Cubs on Monday. Chicago is 17-24 to begin the 2022 campaign.

Caesars Sportsbook lists the Reds as -120 money line favorites, and first pitch is scheduled for 6:40 p.m. ET. The total number of runs Vegas thinks will be scored, or the Over-Under, is 8.5 in the latest Reds vs. Cubs odds. Before you make any MLB predictions with the Cubs vs. Reds match-up, you need to see the MLB predictions and betting advice from SportsLine's advanced computer simulation model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a strong start to the 2022 season. It's on a 41-30 roll on top-rated MLB money-line picks through seven weeks, returning almost $600 for $100 players. Anyone following it has seen huge returns.

Now, the model has set its sights on Cubs vs. Reds. You can head to SportsLine now to see the model's picks. Now, here are several MLB odds and betting lines and trends for Reds vs. Cubs:

  • Cubs vs. Reds money line: Reds -120, Cubs +100
  • Cubs vs. Reds over-under: 8.5 runs 
  • Cubs vs. Reds run line: Reds -1.5 (+175)
  • Cubs vs. Red tickets: See tickets at StubHub
  • CHC: The Cubs are 10-9 in road games 
  • CIN: The Reds are 5-10 In home games
Featured Game | Cincinnati Reds vs. Chicago Cubs

Why you should back the Cubs

Chicago has several advantages against a struggling Cincinnati team, but high on the list is Marcus Stroman. The 31-year-old right-hander takes the ball for the Cubs, and Stroman is a former All-Star. He has a stellar 3.26 ERA since the start of the 2019 season, with that sample covering nearly 400 innings of work. Stroman thwarts right-handed batters to the tune of a .690 OPS allowed in his career, and he has a 2.96 career ERA against the Reds. Stroman also threw seven shutout innings in his last road start, and he has a 3.71 ERA in road tilts in 2022. 

He will also face a Reds offense that is one of the worst in Major League Baseball this season. Cincinnati has the worst on-base percentage (.291) in the National League, with bottom-three marks in runs scored (159), batting average (.217) and slugging percentage (.353). The Reds also have a modest walk rate of only 8.2 percent, and Chicago's bullpen is solidly above-average in overall quality this season.

Why you should back the Reds

The Reds have the benefit of home-field advantage, and Cincinnati has been notably better at Great American Ball Park this season. Cincinnati can also bank on solid production from starting pitcher Tyler Mahle. The 27-year-old right-hander has a 2.60 ERA in his last three starts, generating 18 strikeouts and giving up only five earned runs. 

Mahle is durable, making 42 starts in the last two seasons, and he has a 3.56 career ERA in 13 outings against the Cubs. He is also a potent strikeout artist, averaging 10.4 strikeouts per nine innings over the last three seasons of work. Chicago's offense is also pedestrian in nature, ranking below the National League average in runs scored, stolen bases, batting average and several additional categories.

How to make Cubs vs. Reds picks

SportsLine's model is leaning over on the total, projecting 10 combined runs. It also says one side of the money line has all the value. You can only get the model's MLB picks at SportsLine.

So who wins Cubs vs. Reds? And which side has all the value? Visit SportsLine now to see which side of Cubs vs. Reds you need to jump on Tuesday, all from the model that has crushed its MLB picks, and find out.