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After a day off on Thursday, the San Francisco Giants return to action on Friday evening. The Giants visit Great American Ball Park to take on the Cincinnati Reds in a clash between two National League squads. San Francisco and Cincinnati begin a three-game set, and the two teams have not faced off until this point in 2022. The Reds are struggling to a 14-30 record, with the Giants entering at 24-19 this season.

First pitch is at 6:40 p.m. ET in Cincinnati. Caesars Sportsbook lists San Francisco as a -220 favorite on the money line (risk $220 to win $100), while the over-under, or total number of runs Vegas thinks will be scored, is eight in the latest Giants vs. Reds odds. Before making any Reds vs. Giants picks, you need to see the MLB predictions and betting advice from SportsLine's advanced computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a strong start to the 2022 season. It's on a 41-30 roll on top-rated MLB money-line picks through seven weeks, returning almost $600 for $100 players. Anyone following it has seen huge returns.

Now, the model has set its sights on Giants vs. Reds and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model's picks. Here are several MLB odds and betting lines for Reds vs. Giants:

  • Giants vs. Reds money line: Giants -220, Reds +190
  • Giants vs. Reds over-under: 8 runs
  • Giants vs. Reds run line: Giants -1.5 (-130)
  • Giants vs. Reds tickets: See tickets at StubHub
  • SF: The Giants are 11-8 in road games
  • CIN: The Reds are 7-11 in home games
Featured Game | Cincinnati Reds vs. San Francisco Giants

Why you should back the Giants

The Giants have several strong metrics on the offensive side. San Francisco has 223 runs scored, a top-three mark in the National League, and the Giants also rank in the top three in walks (167), on-base percentage (.331), slugging percentage (.408), and OPS (.739). San Francisco also has top-five marks in total bases (589) and home runs (42), with 30-year-old outfielder Joc Pederson blasting four home runs in the last two games. Pederson has 11 home runs and a .606 slugging percentage this season, and the Giants can also benefit from a subpar Reds bullpen. 

Cincinnati's relief corps has an ugly 4.66 ERA, with poor marks in walk rate (4.51 per nine innings) and ground ball rate (36.5 percent). From there, the Giants are sending Carlos Rodon to the mound, and he is a top-flight starting pitcher. Rodon has a 2.64 ERA since the start of the 2021 season, generating nearly five times as many strikeouts as walks. He leads the NL in strikeout rate this season, with left-handed hitters posting a hideous .074 slugging percentage against Rodon.

Why you should back the Reds

After a disastrous start to the season, Cincinnati is beginning to right the ship. The Reds are 11-8 in the last 19 games, operating like a completely different club. That came to a head on Thursday afternoon when Cincinnati scored 20 runs in a blowout win over the Chicago Cubs, and the Reds generated 20 hits and seven walks in the game. The Reds have 74 doubles this season, a mark well above the NL average, and Cincinnati can perhaps take advantage of a scuffling Giants bullpen. 

San Francisco's relievers have a 4.54 combined ERA this season, ranking in the bottom five of the National League, and the team's bullpen has a dismal strikeout rate of only 7.69 batters per nine innings. On the run prevention side, the Giants are in the bottom five of the National League in both doubles (67) and triples (three), and Cincinnati, which hasn't announced a starter as of Friday morning, has the advantage of playing in front of its home fans.

How to make Reds vs. Giants picks

SportsLine's model is leaning over on the total, projecting 10 combined runs. It also says one side of the money line has all the value. You can only get the MLB model's picks at SportsLine.

So who wins Giants vs. Reds? And which side has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.