The San Francisco Giants (23-19) host the New York Mets (29-16) in the last game of their three-game series on Wednesday afternoon. The Mets had their two-game win streak halted after picking up a 13-12 loss to the Giants on Tuesday night. San Francisco is looking to carry the momentum into this contest.

First pitch is set for 3:45 p.m. ET from Oracle Park. San Francisco is the -125 money line favorite (risk $125 to win $100) in the latest Mets vs. Giants odds from Caesars Sportsbook, while New York is a +105 underdog. The over-under for total runs scored is 8.5. Before making any Giants vs. Mets picks, be sure to check out the latest MLB predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a strong start to the 2022 season. It's on a 41-30 roll on top-rated MLB money-line picks through seven weeks, returning almost $600 for $100 players. Anyone following it has seen huge returns.

Now, the model has set its sights on Mets vs. Giants and locked in its MLB picks and predictions. You can head to SportsLine now to see the model's picks. Here are several MLB odds and betting lines and trends for Giants vs. Mets:

  • Mets vs. Giants money line: San Francisco -125, New York +105
  • Mets vs. Giants run-line: San Francisco -1.5 (+160)
  • Mets vs. Giants over-under: 8.5 runs
  • Mets vs. Giants tickets: See tickets at StubHub
  • SF: The over is 6-0 in Giants' last six vs. National League East opponents
  • NYM: The Mets are 6-1 in their last seven during Game 3 of a series
Featured Game | San Francisco Giants vs. New York Mets

Why you should back the Mets

Right fielder Starling Marte is a great athlete who owns a good power/speed combination. Marte, a two-time Gold Glove winner, plays very good defense in the outfield and has a solid throwing arm. The 2016 All-Star has a batting average of .277 with four home runs and 23 runs driven in. In his last outing, he went 3-for-6 with three singles and two runs scored.

Center fielder Brandon Nimmo is a solid hitter with sound home run power. Nimmo is a playmaker all over the field who can cover lots of ground in the outfield. The 29-year-old currently has a batting average of .295 with three home runs and 16 RBI, and he enters play on an eight-game hitting streak. 

Why you should back the Giants

Left fielder Joc Pederson is a great athlete with outstanding power and bat speed. Pederson can be a patient hitter with sound pitch recognition but has the aggressiveness to turn on a pitch he likes. The 2015 All-Star leads the team in home runs (10) with 22 RBIs and a batting average of .255. Pederson is coming off a monster performance. He went 4-for-6 with three homers and eight RBIs in last night's win. 

Second baseman Wilmer Flores has terrific hands and bat speed. He's able to drive the ball to all parts of the field with regularity. Flores also displayed a very good arm and solid instincts. The 30-year-old owns a batting average of .257 with four home runs and 24 RBIs. On May 20, he was 2-for-5 with two runs driven in. 

How to make Giants vs. Mets picks

SportsLine's model is leaning under on the total, projecting 8.5 runs. It also says one side of the money line has all the value. You can only get the model's MLB picks at SportsLine.

So who wins Mets vs. Giants? And which side has all the value? Visit SportsLine now to see which side of you need to jump on, all from the model that has crushed its MLB picks, and find out.