The San Diego Padres attempt to extend their winning streak to six games when they host the National League Central-leading Milwaukee Brewers in an MLB on TBS matchup on Tuesday. San Diego (28-14) took the three-game series opener 3-2, overcoming an early two-run deficit and winning on rookie Jose Azocar's two-out, walk-off single in the 10th inning. The Padres are one-half game behind the first-place Los Angeles Dodgers in the NL West while Milwaukee (26-16), which has suffered back-to-back losses after winning three straight, owns a two-game lead over St. Louis in the Central.

First pitch from Petco Park is set for 9:40 p.m. ET. Milwaukee is a -135 favorite (risk $135 to win $100) on the money line in the latest Brewers vs. Padres odds from Caesars Sportsbook, while the over-under for total runs scored is 6.5. Before making any Padres vs. Brewers picks, you need to see the MLB predictions and betting advice from SportsLine's advanced computer simulation model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a strong start to the 2022 season. It's on a 41-30 roll on top-rated MLB money-line picks through seven weeks, returning almost $600 for $100 players. Anyone following it has seen huge returns.

Now, the model has set its sights on Padres vs. Brewers and locked in its MLB picks and predictions. You can head to SportsLine now to see the model's picks. Now, here are several MLB odds and betting lines and trends for Brewers vs. Padres:

  • Brewers vs. Padres money line: Milwaukee -135, San Diego +115
  • Brewers vs. Padres over-under: 6.5 runs
  • Brewers vs. Padres run line: Milwaukee -1.5 (+145)
  • Brewers vs. Padres tickets: See tickets at StubHub
  • MIL: The Brewers have lost their last six contests against NL West opponents
  • SD: The Padres have gone 23-9 since splitting their first 10 games of the season
Featured Game | San Diego Padres vs. Milwaukee Brewers

Why you should back the Brewers

Right-hander Corbin Burnes is looking to bounce back from his worst start of the year, a no-decision against Atlanta last Wednesday in which he allowed season highs of four runs and seven hits over six innings. The 27-year-old reigning NL Cy Young Award winner gave up two runs or fewer in each of his six previous outings. Burnes was superb in his only career start at San Diego on April 20, 2021, scattering four hits over six scoreless frames while registering 10 strikeouts en route to victory.

The Brewers are among the top power-hitting teams in the major leagues as they rank fourth with an NL-high 55 home runs. Twelve different players have at least two blasts for the club, with Willy Adames, Rowdy Tellez and Hunter Renfroe (hamstring, out) leading the way with nine apiece. Tellez, who went deep 11 times while splitting last season between Toronto and Milwaukee, also tops the Brewers with 32 RBIs in 40 games.

Why you should back the Padres

San Diego also has one of the game's best pitching staffs as it leads the majors in quality starts (22), is tied with Milwaukee for first in saves and is fifth in strikeouts (385). The Padres are hoping Blake Snell will begin contributing to the already strong starting rotation. The former American League Cy Young Award winner, who missed the beginning of the season with a strained adductor, made his 2022 debut last Wednesday at Philadelphia and yielded three runs and three hits over 3 ⅔ innings.

Offensively, the Padres are led by Manny Machado, who is the top hitter in the majors with a .365 batting average. The five-time All-Star was hitless in four at-bats in the series opener but entered with a six-game hitting streak during which he went 12-for-27 and recorded three multi-hit performances. Machado leads San Diego with eight home runs, 27 RBIs and seven stolen bases.

How to make Brewers vs. Padres picks

SportsLine's model is leaning over on the total, projecting 6.8 runs. It also says one side of the money line has all the value. You can only get the model's MLB picks at SportsLine.

So who wins Padres vs. Brewers? And which side has all the value? Visit SportsLine now to see which side of you need to jump on, all from the model that has crushed its MLB picks, and find out.