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The Cincinnati Reds (60-95) travel to PNC Park to play the Pittsburgh Pirates (58-97) on Wednesday afternoon as these teams wrap up their three-game series. The Pirates are going for the sweep after securing wins in the first two games. Last night, Pittsburgh beat Cincinnati 4-1. The Reds are 2-5 in the last seven meetings in Pittsburgh.

The first pitch is set for 12:35 p.m. ET. The Pirates are listed at -125 in the money line (risk $125 to win $100) in the latest Pirates vs. Reds odds from Caesars Sportsbook. The over-under for total runs scored is 8. Before making any Reds vs. Pirates picks, be sure to see the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it enters the penultimate week of the regular season on a 14-3 run on top-rated money-line picks, returning almost $900 for $100 players. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen huge returns.

Now, the model has set its sights on Pirates vs. Reds and revealed its coveted picks and predictions. You can head to SportsLine to see all of the model's MLB picks. Here are several MLB odds and trends for Pirates vs. Reds:

  • Reds vs. Pirates money line: Pirates -125, Reds +105
  • Reds vs. Pirates run-line: Cincinnati +1.5 (-205)
  • Reds vs. Pirates over-under: 8 runs
  • CIN: Under is 8-1 in Reds' last nine games following a loss
  • PIT: Pirates are 7-3 in their last 10 vs. National League Central
  • Reds vs. Pirates: See picks at SportsLine
Featured Game | Pittsburgh Pirates vs. Cincinnati Reds

Why you should back the Pirates

Third baseman Ke'Bryan Hayes is an exceptional defender who owns amazing instincts and awareness. Hayes uses his strong arm and quick reads to deliver darts across the diamond. The 25-year-old is aggressive at the plate and is hitting .247 with seven home runs and 41 runs driven in.

Second baseman Kevin Newman brings a hot bat into Wednesday's game as he enters on a nine-game hitting streak. That is the second-longest active streak in the NL, and Newman has a .314/.351/.457 split during this stretch. On Monday, he went 2-for-4 with a run scored, a walk and one run driven in.

Why you should back the Reds

Shortstop Kyle Farmer is a natural and solid infielder. Farmer's swing is very smooth and compact with sound pitch recognition skills. The 32-year-old also has superb awareness of the field and it shows. Farmer is batting .255 with 13 dingers, 74 RBI, and on Sept. 21, he went 1-for-3 with two runs driven in.

Outfielder Jake Fraley has supplied some pop from the left side of the plate as he's cracked nine home runs over the last month. Fraley has been especially potent against RHPs as nine of his 10 homers and 23 of his 26 RBI have come against right-handed pitchers. Last month in back-to-back games versus Pittsburgh, Fraley went 3-for-6 with two homers, five walks, five RBI and six runs scored.

How to make Reds vs. Pirates picks

SportsLine's model is leaning Over on the total, projecting 9 combined runs. It also says one side of the money line has all the value. You can only get the model's MLB picks at SportsLine.

So who wins Pirates vs. Reds? And which side has all of the value? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.