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The Minnesota Twins visit the Cleveland Guardians for a doubleheader on Tuesday. The opener begins in the afternoon at Progressive Field, with Cleveland aiming to even the series. Minnesota dominated Monday's series opener by a 10-run margin, improving to 42-33 this season. Cleveland is 36-33 overall and 16-14 at home. 

First pitch is at 1:10 p.m. ET in Cleveland. Caesars Sportsbook lists Cleveland as a -115 favorite (risk $115 to win $100) on the money line, while the over-under, or total number of runs Vegas thinks will be scored, is 8.5 in the latest Twins vs. Guardians odds. Before making any Guardians vs. Twins picks, you need to see the MLB predictions and betting advice from SportsLine's advanced computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a strong start to the 2022 season. It's on a 59-51 run on top-rated MLB money-line picks through 12 weeks. This is the same model that pegged the 2021 Atlanta Braves as one of three best bets to win it all last season at +1000. Anybody who has followed it has seen profitable returns.

Now, the model has set its sights on Twins vs. Guardians, and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model's picks. Here are several MLB odds and betting lines for Guardians vs. Twins:

  • Twins vs. Guardians money line: Twins -105, Guardians -115
  • Twins vs. Guardians over-under: 8.5 runs
  • Twins vs. Guardians run line: Twins -1.5 (+140)
  • MINN: The Twins are 21-14 in day games
  • CLE: The Guardians are 19-18 in day games
Featured Game | Cleveland Guardians vs. Minnesota Twins

Why you should back the Twins

Minnesota showcased its offensive upside on Monday evening. The Twins scored 11 runs on 14 hits in the series opener against the Guardians, blasting three home runs along the way. Minnesota also ranks in the top four of the American League with 339 runs scored, and the underlying numbers are favorable. The Twins are No. 2 in the AL in hits (63), No. 3 in doubles (133), No. 4 in walk rate (8.9 percent), and No. 3 in batting average (.253), with top-five marks in on-base percentage and slugging percentage.

Minnesota also has a strong starting pitcher on the hill in the afternoon matchup, with 26-year-old Devin Smeltzer posting impressive numbers in 2022. He has a 3.05 ERA with a 1.06 WHIP this season, and the Guardians have scored only one run against Smeltzer in two starts and 11 innings. He is a strong control pitcher, issuing only 2.2 walks per nine innings, and left-handed hitters have a .540 OPS against him.

Why you should back the Guardians

Cleveland's offense should be comfortable at home, and the Guardians have an intriguing overall profile. No team in the American League has fewer strikeouts (480) than the Guardians this season, and Cleveland is in the top five of the AL with 129 doubles. Cleveland is also No. 2 in the league with 16 triples, and the Guardians fly around the bases with 47 steals this season. The Guardians have a .249 batting average, and Cleveland is keyed by a legitimate superstar in Jose Ramirez

The three-time All-Star and three-time Silver Slugger has a .300 batting average, .387 on-base percentage and .613 slugging percentage in 2022 with more walks (35) than strikeouts (22) this season. Ramirez also has 16 home runs and 23 doubles, putting consistent pressure on opponents with discipline and power at the plate. 

How to make Guardians vs. Twins picks

SportsLine's model is leaning over on the total, projecting 7.9 combined runs. It also says one side of the money line has all the value. You can only get the model's MLB picks at SportsLine.

So who wins Twins vs. Guardians? And which side has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.