Robert Hanashiro / USA TODAY Sports

The Minnesota Twins will look to continue their recent dominance over the Baltimore Orioles when they meet in the first of a three-game series to help get Monday's MLB Memorial Day schedule underway. The Twins (21-31), fifth in the American League Central, have won the last 15 meetings with Baltimore and 21 of the past 24. The Orioles (17-36), who are fifth in the AL East, 16 ½ games behind first-place Tampa Bay, have not won since a 10-6 triumph over the New York Yankees on May 16. Neither team has played well in May with the Twins going 12-16, while the Orioles are 5-22.

The game from Camden Yards in Baltimore will start at 1:05 p.m. ET. The Twins are ninth in MLB with a .240 team batting average, while the Orioles are 22nd at .231. Minnesota is a -153 favorite (risk $153 to win $100) on the money line in the latest Twins vs. Orioles odds from William Hill Sportsbook, while the over-under for total runs scored is 8.5. Before locking in any Orioles vs. Twins picks, check out the latest MLB predictions and betting advice from the SportsLine Projection Model.

This model, which simulates every pitch of every game 10,000 times, had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line MLB picks. It is off to a fast start in 2021, going 61-44 on top-rated MLB money-line picks through eight weeks, returning well over $700. Anyone following it has seen huge rewards.

Now, the model has dialed in on Twins vs. Orioles. You can visit SportsLine now to see the picks. Here are the MLB lines and trends for Orioles vs. Twins:

  • Twins vs. Orioles money line: Minnesota -153, Baltimore +143
  • Twins vs. Orioles run line: Minnesota -1.5 (-105)
  • Twins vs. Orioles over-under: 8.5 runs
  • MIN: The Twins are 4-0 in their last four games against the American League East
  • BAL: The Over is 5-0 in the Orioles' last five games as a home underdog
Featured Game | Baltimore Orioles vs. Minnesota Twins

Why you should back the Twins

Minnesota will start Jose Berrios (5-2, 3.67 ERA) and the Twins have had Baltimore's number for nearly five years. In last week's series at Target Field, the Twins outscored the Orioles 18-9. Among those entering the series on a hot streak for Minnesota is shortstop Jorge Polanco, who was 3-for-10 with two doubles and three walks in a three-game set against Kansas City this past weekend. In 20 career games against the Orioles, Polanco has had some success with five doubles, one homer and six RBIs.

Also looking to make some noise at the plate for the Twins is infielder Andrelton Simmons, who has torn apart Orioles pitching in his career. In 30 games, Simmons is hitting .364 against Baltimore, including six doubles, two homers and 14 RBIs. He has also walked 12 times and stole four bases. For the season, he is hitting .240 with two homers and 13 RBIs with 16 runs scored.

Why you should back the Orioles

Right-hander Jorge Lopez (1-6, 5.80 ERA) gets the start for Baltimore. He has struck out 45 batters in 45 innings this season, but has also been bitten by walks with 20. He pitched well in his last outing at Minnesota on Wednesday, allowing just three earned runs and four hits in six innings. But he also walked four batters to go along with three strikeouts. In eight career games against the Twins, including five starts, he is 2-2 with a 5.50 ERA, walking six while striking out 16.

Baltimore could be without one of its top hitters in outfielder Trey Mancini, who has been sidelined with an elbow injury. He is listed as day-to-day. Stepping up on offense has been outfielder Cedric Mullins, who is hitting .296 on the season with six homers, 14 RBIs and 25 runs scored. In last week's series against the Twins, Mullins was 4-for-11 (.364) with two walks, a double and two RBIs. This will be his seventh career game against Minnesota.

How to make Orioles vs. Twins picks

SportsLine's model is leaning over on the total, projecting the teams to combine for 9.1 runs, and it also says one side of the money line has all the value. You can only see the pick at SportsLine

So who wins Orioles vs. Twins? And which side of the money line has all the value? Visit SportsLine now to see which side of the money line to jump on, all from the advanced model off to a hot start in 2021.