Robert Hanashiro / USA TODAY Sports

The Boston Red Sox will try to continue their recent success over the rival New York Yankees when they meet in the second game of their three-game series on Saturday night at Fenway Park in Boston. The Red Sox (45-31) have won four straight games against the Yankees (40-35). That includes a 5-3 victory in the series opener on Friday night. With the win Boston remained a ½ game behind the division-leading Rays in the AL East. New York dropped to five games behind.

First pitch is scheduled for 7:15 p.m. ET. The latest Red Sox vs. Yankees odds from William Hill Sportsbook list Boston as the -125 favorite (risk $125 to win $100). The over-under, or total number of runs expected, is set at 10. Before finalizing any Yankees vs. Red Sox picks, check out the latest MLB predictions and betting advice from the SportsLine Projection Model.

This model, which simulates every pitch of every game 10,000 times, had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line MLB picks. It's off to a sizzling start in 2021, going 100-74 on top-rated MLB money-line picks through 12 weeks, returning over $1,200. Anyone following it has seen huge returns.

Now, the model has dialed in on Yankees vs. Red Sox. You can visit SportsLine now to see the picks. Here are the MLB lines and trends for Red Sox vs. Yankees:

  • Red Sox vs. Yankees money line: Boston -125, New York +115
  • Red Sox vs. Yankees run line: Boston -1.5 (+145)
  • Red Sox vs. Yankees over-under: 10 runs
  • BOS: Xander Bogaerts ranks seventh in the majors in batting average (.320)
  • NYY: Bullpen ranks fourth in the majors in ERA (3.15)
Featured Game | Boston Red Sox vs. New York Yankees

Why you should back the Red Sox 

Bogaerts is having a career-best season. The Boston shortstop ranks seventh in the majors in batting average (.320) and 11th in OPS (.930). He also has 13 home runs and 45 RBI. On Friday he knocked in the first runs of the game with a two-run double off Domingo German.

In addition, Nathan Eovaldi (7-4, 3.90) has been solid for the Red Sox this season. He leads the team in wins and has gone five or more innings in 13 of his last 15 starts. When he last faced the Yankees, on June 4, he limited them to one earned run on eight hits over six innings in a 5-2 Boston win.

Why you should back the Yankees

New York has been successful with Jordan Montgomery on the mound this season. The Yankees are 11-3 in Montgomery's 14 starts this year, returning +559 on the money line in those outings. They've won his last six starts by a combined score of 27-17.

In addition, the New York lineup has received a boost with the return of Luke Voit. Since returning from the IL on June 22, the Yankees first baseman is hitting .353 with a 1.212 OPS, two homers and three RBI in just 17 at-bats. He has a hit in all four games he has played since rejoining the lineup.

How to make Red Sox vs. Yankees picks

SportsLine's model is leaning under on the total, projecting the teams to combine for 9.4 runs. It also says one side of the money line has all the value. You can only see the pick at SportsLine

So who wins Red Sox vs. Yankees? And which side of the money line has all the value? Visit SportsLine now to see which side of the money line to jump on, all from the advanced model off to a hot start in 2021.