Watch Now: UFC 250: Nunes Favorited Entering Saturday's Fight (3:12)

With Amanda Nunes, one of the promotion's top stars, facing Felicia Spencer at UFC 250 on Saturday in Las Vegas, the interest in UFC DFS will be sky-high this weekend. FanDuel is running a $400K Saturday UFC Octagon tournament, while DraftKings has a $2.5M MMA Millionaire contest. Preliminary fights start at 6 p.m. ET, while the main UFC 250 fight card begins four hours later. Nunes, a heavy favorite, could be one of the top UFC 250 DFS picks on Saturday.

Nunes, however, is the most expensive option in the MMA DFS fighter pool on both sites, going off at $23 on FanDuel and $9,400 on DraftKings. Is she still worth building UFC 250 DFS lineups around, or does the optimal UFC DFS strategy include loading up on other fighters who may go overlooked? Before locking in any UFC 250 DFS picks, be sure to check out the optimal UFC DFS strategy and advice from SportsLine's Mike McClure.

McClure is a predictive data engineer and DFS pro with almost $2 million in career winnings. He's crushed his DFS selections recently, producing tournament rosters that have cashed huge in multiple sports over the past few years.

At UFC Fight Night: Woodley vs. Burns, McClure was all over Mackenzie Dern and Jamahal Hill as two of his top picks. The results: both fighters scored first-round stoppages, and anybody who followed McClure's advice was poised for a profitable day. 

Now, McClure has set his sights on UFC 250 and locked in his top MMA daily Fantasy picks. You can only see them here.

Top UFC 250 DFS predictions

For UFC 250, McClure is high on Devin Clark, who is going off at $11 on FanDuel and $7,200 on DraftKings, as he takes on Alonzo Menifield in a light heavyweight bout. Clark (11-4) is an underdog against the unbeaten Menifield (9-0). McClure, however, is calling for an upset that would return massive value for UFC 250 DFS players. 

That's because Clark appears to have the edge in wrestling and a chance to pick up the win, especially if he can get his fight to the scorecards. He averages 3.03 takedowns per 15 minutes and has a 42 percent takedown accuracy. If he can avoid a crushing shot from Clark, he should be in it for the full five rounds. McClure is using Clark in his FanDuel lineups and getting the fourth-most exposure from him on DraftKings, making him one of the top MMA DFS picks for Saturday you should be all over.

Part of McClure's optimal UFC 250 DFS strategy also includes rostering Herbert Burns ($8,900 on DraftKings, $18 on FanDuel), who is 10-2 and takes on Evan Dunham in a catchweight bout at 150 pounds. The brother of last week's main event winner Gilbert Burns, Herbert Burns is coming off a dynamic performance in his UFC debut against Nate Landwehr at UFC Fight Night 166.

Burns scored a first-round knockout via a vicious knee and has now recorded three consecutive first-round knockouts. Meanwhile, the 38-year-old Dunham hasn't won since September 2016 and he's been knocked out via knees in each of his last two fights. Look for Burns to score an early decision and rack up the points for UFC daily Fantasy players on Saturday night.

How to make UFC DFS picks

McClure is also targeting a value fighter who is a must-roster because his fight is a huge mismatch. This pick could be the difference between cashing huge in MMA DFS or going home with nothing. You can see all of McClure's MMA DFS picks and advice here.

So what are the optimal DraftKings and FanDuel picks for UFC 250? And which value fighter needs to be in your lineup? Visit SportsLine now to see DFS millionaire Mike McClure's complete optimal picks for Saturday's UFC 250, and cash in big on MMA DFS.