Watch Now: UFC 250 Preview: Aljamain Sterling vs Cory Sandhagen (2:47)

The greatest female mixed martial artist and current two-division champion, Amanda Nunes, returns to the UFC Octagon Saturday to put her women's featherweight championship on the line against Felicia Spencer. The championship bout headlines the action from the UFC Apex facility in Las Vegas as the UFC returns to pay-per-view from their home city for the first time since the coronavirus pandemic threw the world into chaos.

Nunes is on an incredible run, having not lost a fight since 2014. She's racked up wins over a who's who of opponents, including Valentina Shevchenko (twice), Miesha Tate, Ronda Rousey, Cris Cyborg, Holly Holm, Germain de Randamie (twice) and Cris Cyborg. Spencer is no slouch herself as the former Invicta FC featherweight champ. Her lone loss came to Cyborg in a slugfest in 20

Plus, a trio of bantamweight bouts with huge implications on the 135-pound division are on tap with tons of star power. Former champ Cody Garbrandt takes on Raphael Assuncao in the co-main event, Aljamain Sterling faces Cory Sandhagen in a crucial feature bout and "Suga" Sean O'Malley battles former WEC champ Eddie Wineland to kick off the PPV show.

Get your expert picks for UFC 250 from our podcast -- State of Combat with Brian Campbell -- where we look at everything on the main card and get some in-depth analysis from UFC Hall of Famer "Suga" Rashad Evans below.

Below is all the information you need to catch the UFC 250 event on Saturday night. 

How to watch UFC 250 prelims

Date: June 6 | Location: UFC Apex -- Las Vegas, Nevada
Time: 8 p.m. ET
Stream: Watch ESPN | Channel: ESPN

How to watch UFC 250 main card

Date: June 6 | Location: UFC Apex -- Las Vegas, Nevada
Time: 10 p.m. ET
Stream: ESPN+ | Price: $64.99

Now, here's a look at the UFC 250 main fight card and betting odds via Westgate.

UFC 250 main card, odds

FavoriteUnderdogWeightclass

Amanda Nunes (c) -650

Felicia Spencer +475

Women's featherweight title

Cody Garbrandt -150

Raphael Assuncao +125

Bantamweight

Aljamain Sterling -115

Cory Sandhagen -105

Bantamweight

Neil Magny -135

Anthony Rocco Martin +115

Welterweight

Sean O'Malley -575

Eddie Wineland +425

Bantamweight

Who will win Nunes vs. Spencer, and how exactly does each fight end? Visit SportsLine now to get detailed picks on every fight at UFC 250, all from the accomplished MMA expert who's up more than $20,000 and has nailed eight straight main event winners.