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Headlining Saturday's UFC 259 event from the UFC APEX in Las Vegas is major three championship fights, including a battle in the main event between two titleholders. The marquee fight of the night sees middleweight champion Israel Adesanya travel up to the light heavyweight division to challenge 205-pound champion Jan Blachowicz for the belt.

The main event will see middleweight champ Israel Adesanya make the journey 20 pounds north to light heavyweight to challenge light heavyweight king Jan Blachowicz for the 205-pound title. If successful, Adesanya will become the fifth simultaneous two-division champion in promotional history. It would also be the fastest any fighter has accomplished that feat as he makes just his 10th walk to the Octagon on Saturday. 

This card also marks the return of bantamweight champion Petr Yan when he takes on Aljamain Sterling in a much-anticipated clash for the 135-pound title. Plus, lightweight Islam Makhachev makes his first appearance inside the Octagon in 18 months when he takes on the surging Drew Dober. And former light heavyweight title challenger Thiago Santos opens the PPV portion of the card when he faces red-hot Aleksandar Rakic in a critical 205-pound clash.

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Below is all the information you need to catch UFC 259 on Saturday night. 

How to watch UFC 259 prelims

Date: March 6 | Location: UFC APEX -- Las Vegas
Time: 8 p.m. ET
Channel: ESPN | Stream: fuboTV (Try for free)

How to watch UFC 259 main card

Date: March 6 | Location: UFC APEX -- Las Vegas
Time: 10 p.m. ET
Stream: ESPN+ | Price: $69.99

Now, here's a look at the UFC 259 main fight card and betting odds via William Hill Sportsbook.

UFC 259 main card, odds

FavoriteUnderdogWeightclass

Israel Adesanya -230

Jan Blachowicz (c) +190

Light heavyweight title

Amanda Nunes (c) -900Megan Anderson +600Women's featherweight title

Petr Yan (c) -130

Aljamain Sterling +110

Bantamweight title

Islam Makhachev -440

Drew Dober +340

Lightweight

Aleksandar Rakic -175

Thiago Santos +150

Light heavyweight


Who will win Blachowicz vs. Adesanya, and which underdog is a must-back? Visit SportsLine now to get detailed picks on every fight at UFC 259, all from the incomparable expert who's up more than $21,000 on MMA in the past 25 months, and find out.