With Saturday's UFC 265 heavyweight bout between Ciryl Gane vs. Derrick Lewis on the docket, bettors are looking to cash in on the many prop bets available for the event as the main UFC 265 fight card begins at 10 p.m. ET. Among the more popular Lewis vs. Gane prop bets from Caesars Sportsbook are that the fight will last five rounds at +150, and whether Gane will win by TKO at +138. Gane (9-0) has been impressive in his MMA career since turning pro in 2018. He previously competed professionally in Muay Thai, posting a 13-0 record with nine knockouts. Lewis (25-7) is on a four-bout winning streak and is ranked No. 2 in the UFC heavyweight rankings.

There is also a prop bet on whether the bantamweight bout between Jose Aldo and Pedro Munhoz will be won by decision, among many other options on the UFC 265 odds board. So which UFC 265 props should you target? Before making any UFC 265 prop bet picks, be sure to see the UFC 265 predictions from SportsLine's Brandon Wise.

Wise specializes in picking main-card fights for UFC, which has enabled him to be profitable every year. In fact, Wise called Israel Adesanya by decision at +140 and Brandon Moreno to win outright at +190 at UFC 263 earlier this summer. Wise went a perfect 5-0 at UFC 239 and was 4-1 at both UFC 245 and UFC 249.

He also nailed Khabib Nurmagomedov's destruction of Conor McGregor in 2018, Stipe Miocic's defeat of Daniel Cormier, Max Holloway's downfall in 2019 and Justin Gaethje's TKO victory over Tony Ferguson in May of last year. 

Now, with UFC 265: Ciryl Gane vs. Derrick Lewis fast approaching, Wise has carefully studied every main-card matchup and the available props and released his MMA predictions. Successfully parlaying his top UFC 265 picks would lead to a huge payout of more than 18-1. You can only see them here.

Ciryl Gane vs. Derrick Lewis expert preview

Wise believes this will be a hard-fought bout, but says Lewis will need to utilize all his tools to be successful. Lewis has been a professional competitor since April 2010, and is a former Legacy FC heavyweight champion. He also competed for Bellator MMA. Since Feb. 22, he has been ranked No. 2 in the heavyweight division.

Lewis was originally slated to face current champion Francis Ngannou to defend the title. That plan fell through when the promotion moved forward with the contest despite the champion's refusal to defend the title in August, saying he would be ready by September. He won his title just three months earlier and wanted a four-month break between bouts. Lewis' last bout was in February when he knocked out Curtis Blaydes at 1:26 of the second round at UFC Fight Night: Blaydes vs. Lewis.

Gane is a French mixed martial artist, who has competed in MMA since 2018. He formerly competed in professional Muay Thai, where he went 13-0 with nine wins by knockout. Since turning to MMA, he is 9-0 and is ranked No. 3 in the UFC heavyweight division. He has taken advantage of all of his skills, winning three bouts by knockout, three by decision and three by submission.

In his last appearance, he won by unanimous decision over Alexander Volkov on June 26 at UFC Fight Night: Gane vs. Volkov. In February, he won a unanimous decision over Jairzinho Rozenstruik after having knocked out Junior dos Santos in December at UFC 256. That was his first action in a year due to a number of bout cancellations and reschedulings. You can only see who Wise is backing and get his epic 18-1 parlay right here.

Top UFC 265: Lewis vs. Gane predictions

One of the top UFC 265 prop picks that Wise loves: Angela Hill will win her bout with Tecia Torres by decision in their women's strawweight match, returning +180. Hill, 12th in the UFC strawweight rankings, snapped a two-bout losing streak in March, defeating Ashley Yoder by unanimous decision at UFC Fight Night: Edwards vs. Muhammad. In 22 career matches, Hill has compiled a 13-9 record with five wins by knockout and eight by decision.

Torres, ranked 10th in the division, is 12-5 in her career, which began in 2012. Torres opened her career 7-0, including a unanimous decision win over Hill at UFC 188 in June 2015. Since then, however, she is 5-5, although she has won her last two fights. In her last bout, she defeated Sam Hughes at UFC 256. In that match she was awarded a TKO when a doctor stopped the match following the first round.

How to make Gane vs. Lewis prop bets at UFC 265

Wise has locked in several more plus-money UFC 265 prop picks, including one that returns well over 2-1. You can only see which fighters to back here.

Who wins Ciryl Gane vs. Derrick Lewis at UFC 265? And which prop bets should you parlay for a massive 18-1 payout? Visit SportsLine now to see the top UFC 265 predictions and picks, all from the expert who has crushed his UFC picks.

UFC 265 fight card, odds

Derrick Lewis (-310) vs. Ciryl Gane (-380)
Jose Aldo (-130) vs. Pedro Munhoz (+110)
Michael Chiesa (+110) vs. Vicente Luque (-130)
Tecia Torres (-135) vs. Angela Hill (+115)
Song Yadong (-110) vs. Casey Kenney (-110)
Rafael Fiziev (-345) vs. Bobby Green (+285)
Vince Morales (+100) vs. Drako Rodriguez (-120)
Alonzo Menifield (-240) vs. Ed Herman (+200)
Karolina Kowalkiewicz (-125) vs. Jessica Penne (+105)
Manel Kape (-200) vs. Ode Osbourne (+170)
Miles Johns (-200) vs. Anderson Dos Santos (+175)
Melissa Gatto (-130) vs. Victoria Leonardo (+110)
Johnny Munoz (-230) vs. Jamey Simmons (+195)