Walt Harris has not fought since going through a tragic personal experience that forced him to withdraw from his scheduled bout against Alistair Overeem in December. He hopes to use the devastating ordeal as motivation when the heavyweights square off Saturday at UFC Fight Night: Overeem vs. Harris. The main UFC Jacksonville card is scheduled to start at 9 p.m. ET at VyStar Veterans Memorial Arena. Harris pulled out of the previous matchup due to the disappearance of his stepdaughter, who was tragically found murdered in late November.

The southpaw is stepping into the Octagon for the first time in nearly 10 months, while Overeem hasn't fought since December. Harris is a -150 favorite (risk $150 to win $100) while Overeem is a +125 underdog in the latest Overeem vs. Harris odds from William Hill. In the co-main event, Claudia Gedelha (-195) takes on Angela Hill (+165) in a women's strawweight fight. Before making your UFC Fight Night: Overeem vs. Harris picks, make sure to see the UFC predictions from SportsLine MMA analyst Brandon Wise.

A CBS Sports editor specializing in MMA, Wise has been dissecting the sport for five years. He specializes in picking main-card fights for UFC, which has enabled him to be profitable every year. Wise went a perfect 5-0 at UFC 239 and was 4-1 at both UFC 245 and UFC 249. He also nailed Khabib Nurmagomedov's destruction of Conor McGregor in 2018, Stipe Miocic's upset of Daniel Cormier and Max Holloway's downfall in 2019. Across UFC 247, UFC 248 and UFC 249, Wise went an impressive 11-4 with his main-card picks, returning healthy profits for anyone following them.

Wise also nailed the main event of UFC 249 last Saturday, telling SportsLine members to expect Justin Gaethje (+155) to defeat Tony Ferguson (-180) for the interim lightweight title. He argued that Ferguson would have difficulty focusing after having only a month to prepare for Gaethje and lose via TKO, and he was proven correct as the underdog upset "El Cucuy" in the fifth round. Anyone who has consistently followed Wise is way up.

Now, with UFC Fight Night: Overeem vs. Harris fast approaching, Wise carefully has studied every matchup on the main UFC Jacksonville fight card, identified the best value in the UFC odds and released his MMA picks for each fight. He's only sharing those selections here

Overeem vs. Harris expert preview

Wise has considered that Overeem was four seconds away from a third consecutive victory before being knocked out by Jairzinho Rozenstruik on Dec. 7. The setback was the fourth in eight fights for the 39-year-old Dutchman, a stretch that began with a knockout loss against heavyweight champion Stipe Miocic at UFC 203 in September 2016.

Overeem (45-18, 1 NC) has an impressive resume that includes title reigns with Strikeforce and DREAM, as well as a kickboxing crown in K-1 and an ADCC Submission Wrestling World Championship. Prior to the loss to Rozenstruik, Overeem scored first-round TKO wins over Sergei Pavlovich and Aleksei Oleinik.

Harris (13-7, 1 NC) has recorded all 13 of his victories via knockout, including a 12-second destruction of Oleinik in his last bout on July 20. The 36-year-old former Golden Gloves champion is anxious for his chance at Overeem, who is ranked one spot ahead of him at No. 8, after he had to pull out of their scheduled fight in December due to the search for his missing stepdaughter. You can see Wise's full Overeem vs. Harris picks here.

Top UFC Fight Night predictions

One of Wise's UFC Fight Night main-card predictions for Saturday: He is backing Dan Ige (+115) to upset Edson Barboza (-135) in a featherweight bout. 

Ige (13-2) looks to extend his winning streak to six fights after taking a split decision against Mirsad Bektic at UFC 247 in February. Ranked 15th in the division, the 28-year-old Hawaiian is expecting to knock out Barboza on Saturday, even though only three of his career victories have ended in that fashion. 

Barboza (20-8), the 11th-ranked lightweight in the UFC, has lost four of his last five fights but is extremely dangerous with his feet. The 34-year-old Brazilian is a former Ring of Combat and Renaissance MMA lightweight champion. He also held titles in Muay Thai and Submission Wrestling and was the first fighter in UFC history to record a knockout with a wheel kick when he defeated Terry Etim at UFC 142 in January 2012.

How to make UFC Fight Night picks

Wise also has strong picks for Overeem vs. Harris and every other bout on the main UFC Fight Night Saturday main card. He's also backing a "reinvented" fighter who "will want to brawl." Find out who that is and get every pick for every fight on the UFC Fight Night main card at SportsLine

Who wins Overeem vs. Harris? And how exactly does each fight end? Check out the latest odds below and then visit SportsLine now to get detailed picks on every fight on Saturday's main UFC fight card, all from the accomplished expert who has been profitable for five straight years, and find out.

UFC Fight Night: Overeem vs. Harris main card odds

Alistair Overeem (+125) vs. Walt Harris (-150)
Claudia Gadelha (-195) vs. Angela Hill (+165)
Dan Ige (+115) vs. Edson Barboza (-135)
Eryk Anders (+130) vs. Krzysztof Jotko (-155)
Song Yadong (-180) vs. Marlon Vera (+155)