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The Cleveland Cavaliers aim to keep their positive momentum going on Saturday evening. The Cavaliers visit the Philadelphia 76ers, with Cleveland winning two in a row and Philadelphia winning four of its last five contests. Cleveland is an ugly 3-12 on the road, and Philadelphia is a dominant 14-2 in home games this season. Tobias Harris (knee) is out for the 76ers. Taurean Prince (personal), Kevin Love (calf), Andre Drummond (personal) and Larry Nance (hand) will miss Saturday's game for Cleveland.

Tipoff is at 7 p.m. ET in Philadelphia. William Hill Sportsbook lists the 76ers as 11-point home favorites, while the over-under, or total number of points Vegas thinks will be scored, is 222 in the latest 76ers vs. Cavaliers odds. Before you make any Cavaliers vs. 76ers picks, be sure to see the NBA predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every NBA game 10,000 times, and it returned over $5,000 in profit on its top-rated NBA picks last season. The model also is up almost $8,700 on top-rated NBA picks over the past two-plus seasons. Dating back to last season, it enters Week 10 of the 2020-21 NBA schedule on a stunning 85-49 roll on top-rated NBA picks against the spread. Anybody who has followed it has seen huge returns.

Now, the model has set its sights on 76ers vs. Cavaliers. You can head to SportsLine to see its picks. Now, here are several NBA odds and betting trends for 76ers vs. Cavaliers:

  • 76ers vs. Cavaliers spread: 76ers -11
  • 76ers vs. Cavaliers over-under: 222 points
  • 76ers vs. Cavaliers money line: 76ers -650, Cavaliers +475
  • PHI: 76ers are 5-5 against the spread in the last 10 games
  • CLE: Cavaliers are 2-8 against the spread in the last 10 games

Why the 76ers can cover

Philadelphia has the advantage in high-end talent against Cleveland, especially with regard to Joel Embiid and Ben Simmons. Embiid is a leading MVP candidate, averaging 29.6 points and 11.2 rebounds per game, and Simmons adds 15.7 points, 8.1 rebounds and 7.9 assists per game to go with game-changing defensive impact. On top of that leading duo, the 76ers are also facing a Cavaliers team that has shaky underlying metrics. 

The Cavaliers have the worst point differential in the NBA, with opponents outscoring Cleveland by 8.6 points per 100 possessions, and the Cavs are second-worst in offensive rating, scoring 104.8 points per 100 possessions. Cleveland is also a bottom-three team in effective field goal shooting on both ends, yielding a 55.9 percent clip to opponents and only converting shots at a 50.7 percent rate offensively. That is a difficult gap to overcome, particularly against a stout team like the 76ers.

Why the Cavaliers can cover

Cleveland is playing improved basketball recently, and the team has an intriguing young core. Collin Sexton leads the way with 23.1 points per game and is burying 40.1 percent of his three-point attempts this season. Since arriving from Brooklyn via trade, Jarrett Allen is also playing at a high level, averaging 14.8 points and 9.3 rebounds. As a team, the Cavaliers are No. 3 in the NBA in offensive rebounding, securing 29.7 percent of their own misses off the glass. 

Defensively, Cleveland has been inconsistent, but the Cavs rank in the top 10 in steals (8.3 per game), blocked shots (5.3 per game) and second-chance points allowed (11.9 per game). The Cavs are also above average in preventing their opponents from taking free throws, which is pivotal against Philadelphia.

How to make 76ers vs. Cavaliers picks

SportsLine's model is leaning under on the total, projecting both teams combine for 219 points. The model also says one side of the spread hits in nearly 60 percent of simulations. You can get that pick at SportsLine.

So who wins 76ers vs. Cavaliers? And which side of the spread hits nearly 60 percent of the time? Visit SportsLine now to find out which side of the spread you need to jump on, all from the model that has crushed its NBA picks.