The Boston Celtics and Philadelphia 76ers meet at TD Garden on Wednesday evening. The contest will be the second matchup between the teams this season, with Boston winning the first game on opening night in October. Boston leads the NBA with a 38-16 record, including a 20-7 mark at home, and Philadelphia is 34-18 overall and 14-10 on the road. Joel Embiid (foot) is listed as questionable to play for Philadelphia. Marcus Smart (ankle) is out for Boston, with Robert Williams III (ankle), and Al Horford (knee) listed as questionable.

Caesars Sportsbook lists Boston as a 4-point favorite, and tip-off is scheduled for 7:30 p.m. ET. The total number of points Vegas thinks will be scored, or the over/under, is 224.5 in the latest 76ers vs. Celtics odds. Before you make any NBA predictions with the Celtics vs. 76ers match-up, be sure to see the NBA predictions and betting advice from SportsLine's proven model

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit for $100 players on its top-rated NBA picks over the past four-plus seasons. The model enters Week 17 of the 2022-23 NBA season on a stunning 52-28 roll on all top-rated NBA picks this season, returning nearly $2,000. Anyone following it has seen huge returns.

Now, the model has set its sights on 76ers vs. Celtics and just locked in its picks and NBA predictions. You can head to SportsLine now to see the model's picks. Here are several NBA odds and betting lines for Celtics vs. 76ers:

  • 76ers vs. Celtics spread: Celtics -4
  • 76ers vs. Celtics over/under: 224.5 points
  • 76ers vs. Celtics money line: Celtics -190, 76ers +158
  • PHI: The 76ers are 12-12 against the spread in road games
  • BOS: The Celtics are 14-13 against the spread in home games
  • 76ers vs. Celtics picks: See picks at SportsLine
Featured Game | Boston Celtics vs. Philadelphia 76ers

Why the 76ers can cover

Philadelphia is stout on both ends of the floor, ranking in the top eight of the NBA in offensive rating (115.3) and defensive rating (111.5). The 76ers are excellent from a shooting standpoint, ranking in the top five of the league in 3-point accuracy (38.5%) and free throw accuracy (82.5%) while shooting 48.2% from the field. Philadelphia is also above-average in free throw creation and ball security (14.1% turnover rate), and the 76ers maximize possessions as a result. 

On defense, the 76ers are No. 1 in the league in 3-point defense, with opponents shooting 34.2% from beyond the arc. Philadelphia is in the top 10 in turnover creation, forcing 15.3 giveaways per game, and the 76ers also average 8.0 steals per game. The 76ers round out the balanced defensive approach with top-10 marks in assists allowed (24.0 per game) and points allowed in the paint (48.9 per game).

Why the Celtics can cover

Boston's defense is operating at a tremendous level. The Celtics are giving up only 110.5 points per 100 possessions, No. 4 in the NBA, and Boston leads the league defensive rebound rate (74.9%). Opponents produce only 12.7 second-chance points per game against Boston, and the Celtics are holding opponents to 46.5% shooting from the field and 35.1% shooting from 3-point range. Boston is also in the top quartile of the NBA in blocked shots (5.4 per game), fast break points allowed (12.9 per game) and points allowed in the paint (48.3 per game), with a number of strong metrics on offense.

The Celtics lead the league in free throw accuracy (82.9%) on the offensive end, and Boston is in the top eight in 3-pointers per game and 3-point accuracy. That two-way brilliance leads the Celtics to the NBA's best net rating (+6.2), and Boston is out-scoring opponents by 9.2 points per 100 possessions in home games.

How to make Celtics vs. 76ers picks

SportsLine's model is leaning Over on the total, predicting a combined 234 points. The model also says one side of the spread has all the value. You can only get the pick at SportsLine.

So who wins 76ers vs. Celtics? And which side of the spread has all the value? Visit SportsLine now to see which side of the Celtics vs. 76ers spread you need to jump on Wednesday, all from the model that has crushed its NBA picks, and find out.