The San Antonio Spurs (14-38) have won just two of their last 15 games and face a daunting matchup on Friday against a Philadelphia 76ers (33-17) side that has won eight of its last nine. The Spurs were able to notch a victory against Philadelphia in their third game of the season in October, but the 76ers have won in three of their last four trips to San Antonio. Philadelphia center Joel Embiid (foot) is listed as questionable, but has played through his ailment for the last four games and scored 47 points last Saturday against the Denver Nuggets.

Tip-off from the AT&T Center, where the Spurs are 9-20 this season, is set for 8 p.m. ET. Philadelphia is favored by 10.5 points in the latest Spurs vs. 76ers odds from Caesars Sportsbook, and the over/under is set at 234.5. Before entering any 76ers vs. Spurs picks, you'll want to see the NBA predictions from the model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit for $100 players on its top-rated NBA picks over the past four-plus seasons. The model enters Week 16 of the 2022-23 NBA season on a stunning 49-23 roll on all top-rated NBA picks this season, returning nearly $2,300. Anyone following it has seen huge returns.

Now, the model has set its sights on 76ers vs. Spurs. You can head to SportsLine to see its picks. Here are several NBA betting lines for Sixers vs. Spurs:

  • 76ers vs. Spurs spread: 76ers -10.5
  • 76ers vs. Spurs over/under: 234.5 points
  • 76ers vs. Spurs money line: Philadelphia -480, San Antonio +360
  • 76ers vs. Spurs picks: See picks here
Featured Game | San Antonio Spurs vs. Philadelphia 76ers

What you need to know about the 76ers

After they dropped the first of back-to-back games against the Orlando Magic, the 76ers got the last laugh with a 105-94 win on Wednesday. Embiid finished with 28 points, 11 rebounds and made all 10 of his free throws. James Harden was right behind, with 26 points and 10 assists, and he missed out on a triple-double by just one rebound.

Philadelphia is 9-1 in its last 10 games and has hit 41.6% of its 3-point attempts during that run. On the other end of the floor, the 76ers have held opponents to just 33.3% from downtown. Over its last three games, San Antonio has allowed its opposition to hit 39.5% of their threes, so Philly should continue to let shots fly from deep on Friday.

What you need to know about the Spurs

The Spurs just didn't have enough firepower to outlast the Sacramento Kings on Wednesday in a 119-109 defeat. Keldon Johnson and Jakob Poeltl each scored 18 points in the loss, and the latter also pulled down 12 rebounds. Making matters worse is that starters Tre Jones (foot) and Jeremy Sochan (back) both left the game early with injuries and aren't expected to play on Friday, nor is second-leading scorer Devin Vassell (knee).

Johnson and Poeltl are the only starters expected to be available against Philadelphia, as shooting guard Romeo Langford (adductor) will also miss the game. The outlook without them isn't great, as over the last five games, the Spurs bench has only shot 44% from the field. The most productive reserve for San Antonio this season has been Josh Richardson (11.4 PPG, 3.2 APG), and the Spurs will need him to step up on Friday.

How to make 76ers vs. Spurs picks

The model has simulated Spurs vs. 76ers 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread holds all of the value. You can only see the pick at SportsLine.

Who wins 76ers vs. Spurs? And which side of the spread is a must-back? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NBA picks, and find out.