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The Philadelphia 76ers will take on the Minnesota Timberwolves at 6 p.m. ET on Saturday at the Wells Fargo Center. The Sixers are 10-9 overall and 4-4 at home, while Minnesota is 9-10 overall and 3-4 on the road. It's a 76ers squad that has been treading water the last nine games without Joel Embiid in the lineup (health and safety protocols), but there's potential that he returns to action on Saturday.

The Sixers won and covered both of their head-to-head matchups with the Timberwolves last season, but that was with Embiid and Ben Simmons, who hasn't played yet this year (personal). Philadelphia is favored by five points in the latest 76ers vs. Timberwolves odds from Caesars Sportsbook, and the over-under is set at 216. Before entering any Timberwolves vs. Sixers picks, you'll want to see the NBA predictions from the model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $9,000 in profit on its top-rated NBA picks over the past three-plus seasons. The model enters Week 6 of the 2021-22 NBA season up over $1,200 on all top-rated NBA picks this season. It's also on a stunning 115-76 roll on top-rated NBA picks against the spread that dates back to last season. Anyone following it has seen huge returns.

Now, the model has set its sights on Sixers vs. Timberwolves. You can head to SportsLine to see its picks. Here are several NBA betting lines for Timberwolves vs. Sixers:

  • 76ers vs. Timberwolves spread: 76ers -5
  • 76ers vs. Timberwolves over-under: 216 points
Featured Game | Philadelphia 76ers vs. Minnesota Timberwolves

What you need to know about the 76ers

The 76ers took a tough 116-96 loss to the Golden State Warriors on Wednesday. One thing holding Philadelphia back was the mediocre play of power forward Georges Niang, who finished with only nine points on 4-for-11 shooting in his 25 minutes on the court.

In addition to missing Embiid and Simmons, Tobias Harris has also missed the last two games with a hip injury, and he's questionable for Saturday's contest. Tyrese Maxey (18.7 ppg) and Seth Curry (15.9 ppg) will be viewed as the primary scorers if Embiid and Harris can't go and Andre Drummond will also have to be a more effective low-post scorer.

What you need to know about the Timberwolves

Meanwhile, Minnesota lost to the Charlotte Hornets on the road by a decisive 133-115 margin. Center Karl-Anthony Towns put forth a good effort for the losing side as he had 25 points and six assists in addition to seven rebounds. Towns, Anthony Edwards and D'Angelo Russell give the Timberwolves a dynamic trio of scorers.

However, it's actually been the defense that has been more consistent in the early part of the season. The Timberwolves rank 10th in the NBA in defensive rating (106.5) and they've rotated and closed out on shooters particularly effectively. Their opponents are shooting just 31.7 percent from the 3-point line, which is the second-best mark in the NBA.

How to make Timberwolves vs. 76ers picks

The model is leaning over on the total and it's also generated a point-spread pick that is hitting in almost 70 percent of simulations. You can only see the pick at SportsLine.

So who wins Sixers vs. Timberwolves And which side of the spread hits in nearly 70 percent of simulations? Visit SportsLine now to see which side of the spread, all from the model that has crushed its NBA picks, and find out.