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The Portland Trail Blazers take on the Cleveland Cavaliers at Rocket Mortgage FieldHouse on Wednesday. Portland (36-29) recently won four games in a row before losing to the Atlanta Hawks on Monday. The Cavaliers (21-44) forced overtime before yielding to the Phoenix Suns on Tuesday. Cleveland is on the second night of a back-to-back, and guard Darius Garland (ankle) remains day-to-day. Damian Lillard (foot) is probable for the Blazers, with Norman Powell (knee) officially listed as questionable. 

Tip-off is set for 7:30 p.m. ET in Cleveland. The latest Blazers vs. Cavaliers odds from William Hill Sportsbook list Portland as the 12-point road favorite. The over-under for total points is set at 227. Before finalizing any Cavaliers vs. Blazers picks, be sure to see the NBA predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned over $9,200 in profit on its top-rated NBA picks over the past two-plus seasons. The model is up over $1,200 on its top-rated picks this season and entered Week 20 of the 2020-21 NBA schedule on a stunning 97-62 roll on top-rated NBA picks against the spread dating back to last season. Anybody who has followed it has seen huge returns.

Now, the model has set its sights on Trail Blazers vs. Cavaliers. You can head to SportsLine to see its picks. Now, here are several NBA odds and betting trends for Cavaliers vs. Trail Blazers:

  • Blazers vs. Cavaliers spread: Blazers -12
  • Blazers vs. Cavaliers over-under: 227 points
  • Blazers vs. Cavaliers money line: Blazers -900, Cavaliers +600
  • POR: The Blazers are 6-4 against the spread in the last 10 games
  • CLE: The Cavaliers are 1-9 against the spread in the last 10 games

Why the Blazers can cover

Portland is keyed by one of the NBA's best backcourts, giving them a leg up in most matchups. Lillard is a top-tier shot creator, averaging 28.4 points and 7.6 assists per game, and he projects as the best player on the floor in this matchup. CJ McCollum provides a stellar secondary option for Portland, putting up 23.1 points and 4.8 assists per game. As a result, the Blazers are a top-five offensive team, scoring more than 1.16 points per possession, and they project to pour it on against Cleveland. Defensively, the Blazers are less impressive on the whole, but they do benefit from the shaky Cleveland offense. 

The Cavaliers are scoring only 1.05 points per possession for the season, and Cleveland is also last in the NBA in 3-pointers per game. Cleveland is a bottom-three squad in shooting efficiency, and the Cavs also struggle to take care of the ball, committing a turnover on almost 16 percent of offensive possessions for the season.

Why the Cavaliers can cover

The Cavaliers are struggling on offense, but they have a path to success against Portland. Cleveland is excellent on the offensive glass, grabbing almost 28 percent of its own missed shots. From there, the Blazers have a porous defense. Portland ranks 29th in the NBA in overall defensive rating, yielding nearly 1.16 points per possession, and the Blazers land below the league's average baseline virtually across the board. On the opposite end, the Cavaliers create havoc at a high level defensively, generating a turnover on approximately 15 percent of defensive possessions. 

Cleveland is a top-10 team in steals per game, and the Cavs also channel their aggression responsibly, boasting a top-10 mark in free throw rate allowed. The Cavaliers will need to protect the defensive glass, and they are a top-eight team in second-chance points allowed, giving up fewer than 12 per game. While Portland is dynamic on the perimeter from a scoring perspective, the Blazers also rank last in assists (21.0 per game), and they are reliant on tough shotmaking.

How to make Cavaliers vs. Blazers picks

SportsLine's model is leaning over on the total, projecting the teams to combine for 230 points. The model also says one side of the spread hits well over 50 percent of the time. You can get that pick at SportsLine.

So who wins Cavaliers vs. Blazers? And which side of the spread hits well over 50 percent of the time? Visit SportsLine now to find out which side of the spread you need to jump on, all from the model that is on a roll on NBA picks.