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Two offensive powerhouses will help wrap up Wednesday's 10-game NBA slate in a Western Conference matchup. The Portland Trail Blazers (1-2) will host the Memphis Grizzlies (2-1) at the Moda Center. The home team hopes to rebound from a blowout loss to the Los Angeles Clippers. The visitors could get back on track after having a two-game winning streak snapped by the Los Angeles Lakers on Sunday.

Tip-off is set for 10 p.m. ET. Caesars Sportsbook lists the Trail Blazers as 2.5-point favorites, while the over-under is 234 in the latest Grizzlies vs. Blazers odds. Before you make any Blazers vs. Grizzlies picks and NBA predictions, you need to see what SportsLine's advanced computer simulation model has to say.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned almost $9,000 in profit on its top-rated NBA picks over the past three-plus seasons. The model finished up almost $600 on its top-rated picks last season and enters Week 2 of the 2021-22 NBA season on a stunning 103-68 roll on top-rated NBA picks against the spread. Anyone following it has seen huge returns.

Now, the model has set its sights on Grizzlies vs. Blazers and revealed its coveted picks and predictions. You can head to SportsLine to see all of the model's NBA picks. Here are several NBA betting lines and trends for Blazers vs. Grizzlies:

  • Grizzlies vs. Trail Blazers spread: Blazers -2.5
  • Grizzlies vs. Trail Blazers over-under: 234 points 
  • Grizzlies vs. Trail Blazers money line: Blazers -140, Grizzlies +120
  • MEM: The Grizzlies are 3-0 against the spread
  • POR: The over has hit in six of the Trail Blazers' previous seven home games
Featured Game | Portland Trail Blazers vs. Memphis Grizzlies

Why the Grizzlies can cover

The Grizzlies aren't completely healthy but have exceeded expectations so far. Desmond Bane and De'Anthony Melton have been quality fill-ins for the injured Dillon Brooks (hand/thigh). Their efficient scoring has helped Memphis lead the NBA in points per game (123.3) early on. In year three, Ja Morant has ascended into a scoring leader candidate and leads the league in points per game (35). His consistent offense has powered Memphis to a 3-0 start against the spread.

Meanwhile, Portland's star point guard is going through a rough patch. Damian Lillard's shooting struggles have had a massive impact on Portland's success. He's shooting less than 40 percent from the field through three games, and his 3-point shooting percentage is even more abysmal. Lillard has converted just 8.3 percent of his shots from beyond the arc. 

Why the Trail Blazers can cover

The Blazers are 1-2 against the spread but have shown promise against quality opponents. Their lone win this season came against the Phoenix Suns, who are known as one of the NBA's premier defensive teams. The Grizzlies are on the opposite end of the spectrum. A hot shooting night for Lillard could help Portland pull away early against a team that's struggled to stop their opponents.

Memphis has a league-worst defensive rating of 117.1. The Grizzlies have given up an average of more than 118 points per game, which is on par with what last season's worst scoring defense gave up. Last season, the Blazers had a top-five scoring offense and offensive rating and brought back the same core. Their middle-of-the-pack defense could be enough to edge out the Grizzlies in a shootout.

How to make Trail Blazers vs. Grizzlies picks

SportsLine's model is leaning under on the point total, projecting these two teams combine for 227 points. The model also says one side of the spread hits in over 50 percent of simulations. You can only see the model's Blazers vs. Grizzlies picks at SportsLine.

So who wins Grizzlies vs. Blazers? And which side of the spread hits in over 50 percent of simulations? Visit SportsLine now to find out which side of the spread you need to jump on Wednesday, all from the model that has crushed its NBA picks, and find out.