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Two of the best teams in the Eastern Conference take the floor at Wells Fargo Center on Friday evening. The Philadelphia 76ers welcome the Brooklyn Nets to town, with the Sixers aiming for a second straight win. Philadelphia began the 2021-22 regular season with a drubbing of the New Orleans Pelicans. Brooklyn aims to bounce back from a season-opening loss to the Milwaukee Bucks in the NBA's opening night showcase. Brooklyn is without Kyrie Irving (medical protocols), while Ben Simmons isn't expected to play for the Sixers as he deals with a back injury and an uncertain future with the team. Joel Embiid remains listed as questionable (knee).

Tip-off is at 7:30 p.m. ET in Philadelphia. Caesars Sportsbook lists Brooklyn as a 2.5-point favorite in the latest Nets vs. Sixers odds. The over-under for total points is set at 226. Before making any 76ers vs. Nets odds, be sure to see the NBA predictions and betting advice from SportsLine's proven model

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned almost $9,000 in profit on its top-rated NBA picks over the past three seasons. The model finished up almost $600 on its top-rated picks last season and enters the 2021-22 NBA season on a stunning 100-66 roll on top-rated NBA picks against the spread. Anyone following it has seen huge returns.

Now, the model has set its sights on Nets vs. 76ers and just released its coveted NBA picks and predictions. You can head to SportsLine now to see the model's picks. Now, here are several NBA betting lines and trends for Sixers vs. Nets:

  • Nets vs. 76ers spread: Nets -2.5
  • Nets vs. 76ers over-under: 226
  • Nets vs. 76ers money line: Nets -145, 76ers +125
  • BKN: The Nets are 21-21 against the spread in the last 42 road games 
  • PHL: The 76ers are 25-17-1 against the spread in the last 43 home games
Featured Game | Philadelphia 76ers vs. Brooklyn Nets

Why the Nets can cover

Brooklyn's offense is devastating, even with Irving out of the picture. Kevin Durant remains one of the NBA's best players, putting up 32 points and 11 rebounds in the season opener. James Harden added 20 points, eight rebounds and eight assists after continuing his statistical brilliance last season in his first season with the Nets. Brooklyn led the NBA in offensive rating, putting up 117.3 points per 100 possessions, and the Nets were a top-two team in field-goal percentage (49.4 percent), 2-point percentage (56.5 percent) and 3-point percentage (39.2 percent). 

The Nets were also a top-10 team in both free-throw volume and accuracy, with the No. 7 mark in assists, averaging 26.8 per game. The Nets are not as elite on defense, but Brooklyn did rank in the top 10 in myriad categories last season, including field-goal percentage defense, 2-point defense, free-throw prevention and blocked shots.

Why the 76ers can cover

Philadelphia's off-court situation with Simmons is drawing headlines, but the 76ers played quite well in their season opener against New Orleans on the road. Four players scored at least 20 points, a rarity in NBA circles, and second-year guard Tyrese Maxey shined with 20 points, seven rebounds and five assists in a larger role. 

Especially if Embiid plays, the 76ers have a lot to like on both ends of the floor, and they have the benefit of home-court advantage in this matchup. Brooklyn scuffled in the opener, and the Nets are weakened by the continued absence of Irving. The 76ers are the better defensive team in this matchup, posting a top-three mark in overall defensive efficiency last season, and Philadelphia was a blistering 29-7 in regular season home games during the 2020-21 campaign. 

How to make Nets vs. 76ers picks

SportsLine's model is leaning over on the total, with three players projected to score more than 25 points. The model also says one side of the spread hits in over 60 percent of simulations. You can only see the model's Sixers vs. Nets pick at SportsLine.

So who wins Nets vs. 76ers? And which side of the spread hits in over 60 percent of simulations? Visit SportsLine now to find out which side of the Nets vs. 76ers spread you need to jump on Friday, all from the model that has crushed its NBA picks, and find out.