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The Philadelphia 76ers travel to face the Boston Celtics in an important Eastern Conference matchup on Tuesday. The Celtics, currently the No. 7 seed in the East, need a win to boost their NBA playoff picture outlook. Boston is just 25-25 this season, though Brad Stevens' team has won two in a row. Philadelphia is 34-16 after a loss to Memphis in its last outing. Tristan Thompson (health and safety) and Evan Fournier (protocols) are out for the Celtics, with George Hill (thumb) sidelined for the 76ers.

Tip-off in Boston is set for 7:30 p.m. ET. The latest Sixers vs. Celtics odds from William Hill Sportsbook list Philadelphia as a two-point road favorite. The over-under for total points expected is set at 221.5. Before finalizing any Celtics vs. Sixers picks, be sure to see the NBA predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every NBA game 10,000 times, and it has returned almost $8,900 in profit on its top-rated NBA picks over the past two-plus seasons. The model is up almost $900 on its top-rated picks this season, and dating back to last year, it entered Week 16 of the 2020-21 NBA schedule on a stunning 93-59 roll on top-rated NBA picks against the spread. Anybody who has followed it has seen huge returns.

Now, the model has set its sights on 76ers vs. Celtics. You can head to SportsLine to see its picks. Now, here are several NBA odds and betting trends for Celtics vs. 76ers:

  • 76ers vs. Celtics spread: 76ers -2
  • 76ers vs. Celtics over-under: 221.5 points
  • 76ers vs. Celtics money line: 76ers -130, Celtics +110
  • PHI: The 76ers are 5-5 against the spread in the last 10 games
  • BOS: The Celtics are 6-4 against the spread in the last 10 games
Featured Game | Boston Celtics vs. Philadelphia 76ers

Why the Sixers can cover

The 76ers are led by top-tier talent, headlined by Joel Embiid. Embiid has been arguably the best player in the NBA on a per-game basis this season, averaging 29.8 points and 11.3 rebounds per game with top-flight rim protection on the defensive end. Tobias Harris adds an offensive punch, averaging 20.8 points per game and shooting 52.5 percent from the floor and 40.1 percent from 3-point range. 

From there, Ben Simmons is an elite defensive force, covering players up and down the positional spectrum, and he adds 15.2 points, 7.9 rebounds and 7.2 assists per game for the season. All told, the 76ers are an elite defensive team, and they have a few edges against the Celtics due to Boston's weaknesses. The Celtics land in the bottom tier in both creating free throws offensively and preventing free throws defensively, with a below-average defensive rebound rate that could leave them vulnerable against Philadelphia.

Why the Celtics can cover

Boston is led by the potent wing duo of Jayson Tatum and Jaylen Brown, with each averaging more than 24 points and five rebounds per game. They are both effective two-way players, leading the Celtics to an above-average mark in both offensive and defensive efficiency. Boston is a top-10 team in the league in net rating (+1.7), and that net rating grows to an outstanding +4.7 in home games. The Celtics are a top-five offensive rebounding team in the NBA, grabbing 29.3 percent of their own missed shots, and they are above-average in effective field goal percentage (54.2 percent). 

Defensively, Boston lands above the league's baseline in turnover creation, with Philadelphia turning the ball over on 14.9 percent of their offensive trips. Finally, the Celtics are a top-10 team in both steals (8.1 per game) and blocks (5.2 per game), with the ability to create defensive havoc.

How to make Celtics vs. Sixers picks

SportsLine's model is leaning over the total, projecting the teams to combine for 223 points. The model also says one side of the spread has all the value. You can get that pick at SportsLine.

So who wins Celtics vs. Sixers? And which side of the spread has all the value? Visit SportsLine now to find out which side of the spread you need to jump on, all from the model that on a roll on NBA picks.