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The Philadelphia 76ers aim to continue their home-court brilliance on Friday evening. Doc Rivers and his team welcome the Boston Celtics to Wells Fargo Center for a rematch of a Philadelphia victory on Wednesday evening. The Sixers are 8-1 at home this season after posting a 31-4 home record in 2019-20. Boston is 8-5 overall this season and 4-3 on the road. The Celtics will be without Jayson Tatum (protocols), with the 76ers operating without Mike Scott (knee) in this game. Tip-off is set for 7:30 p.m. ET.

The latest Celtics vs. Sixers odds from William Hill Sportsbook list Philadelphia as a 4.5-point favorite. The over-under for total points expected is set at 221.5. Before making any Sixers vs. Celtics picks, be sure to see the NBA predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every NBA game 10,000 times, and it returned over $5,000 in profit on its top-rated NBA picks last season. The model is up nearly $8,100 over the past two-plus seasons. Dating back to last season, it is also on a stunning 68-39 roll on top-rated picks against the spread, returning almost $2,500 on those selections alone. Anybody who has followed it has seen huge returns.

Now, the model has set its sights on 76ers vs. Celtics. You can head to SportsLine to see its picks. Now, here are several NBA odds and betting trends for Celtics vs. 76ers:

  • Celtics vs. 76ers spread: 76ers -4.5
  • Celtics vs. 76ers over-under: 221.5
  • BOS: The Celtics are 6-3 against the spread in the last nine games
  • PHIL: The 76ers are 5-5 against the spread in the last 10 games

Why the Celtics can cover

The Celtics remain short-handed without Tatum, but Boston still has a talented roster. Jaylen Brown leads the way with 25.8 points and 5.8 rebounds per game, with Kemba Walker returning to action and others providing support. In fact, Daniel Theis had an explosive game against Philadelphia this week, scoring 23 points and grabbing 10 rebounds, and he could be an X-factor in the rematch. Boston deploys an above-average offense, scoring 1.11 points per possession, and the Celtics are a top-five offensive rebounding team in the league, pulling down 29.6 percent of their own missed shots. 

Defensively, Boston should be able to force turnovers, as the Sixers give the ball away on 16.2 percent of possessions, a bottom-five rate in the league. The Celtics rank in the top 10 in the NBA in both steals (8.5 per game) and blocks (5.5 per game).

Why the Sixers can cover

Philadelphia won the first matchup between the two teams this week and, especially given the absence of Tatum, the 76ers seem to be in a positive position. Joel Embiid was completely dominant in that outing, scoring 42 points and grabbing 10 rebounds, and the All-NBA center is averaging 26.4 points and 11.3 rebounds per game. Tobias Harris provides support with 19.3 points and 6.8 rebounds per contest, and Ben Simmons is a multi-faceted player with contributions on both ends. 

The Celtics also have some weaknesses for the 76ers to exploit, which shouldn't be overlooked. Boston turns the ball over on 15.6 percent of their offensive possessions, a strongly below-average figure compared to other NBA teams, and that could spur Philadelphia's transition offense. From there, the Celtics are fourth-worst in the NBA in free throw rate allowed, paving the way to the charity stripe for the 76ers on Friday.

How to make Sixers vs. Celtics picks

SportsLine's model is leaning over the total as the simulations are projecting 227 combined points. The model also says one side of the spread hits in well over 50 percent of simulations. You can get that pick at SportsLine.

So who wins Celtics vs. 76ers? And which side of the spread hits well over 50 percent of the time? Visit SportsLine now to find out which side of the Celtics vs. 76ers spread you need to jump on, all from the model that has crushed its NBA picks.