The Los Angeles Clippers visit Wells Fargo Center to face the Philadelphia 76ers in a matchup of NBA title contenders on Friday night. The Clippers (39-18) aim to build on a seven-game winning streak, and they topped the 76ers in the first matchup on March 27 in Los Angeles. The 76ers are 21-5 at home, with an Eastern Conference-leading record of 38-17 this season. Tobias Harris (knee) and Dwight Howard (knee) are questionable for Philadelphia, with George Hill (thumb) ruled out. Kawhi Leonard (foot) is questionable for the Clippers, with Serge Ibaka (back) and Patrick Beverley (hand) ruled out.

Tip-off is set for 7 p.m. ET in Philadelphia. The latest Sixers vs. Clippers odds from William Hill Sportsbook list Philadelphia as a three-point favorite. The over-under for total points expected is set at 220.5. Before finalizing any Clippers vs. Sixers picks, be sure to see the NBA predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every NBA game 10,000 times, and it has returned over $9,100 in profit on its top-rated NBA picks over the past two-plus seasons. The model is up over $1,100 on its top-rated picks this season, and dating back to last year, it entered Week 17 of the 2020-21 NBA schedule on a stunning 95-59 roll on top-rated NBA picks against the spread. Anybody who has followed it has seen huge returns.

Now, the model has set its sights on Clippers vs. 76ers. You can head to SportsLine to see its picks. Now, here are several NBA odds and betting trends for 76ers vs. Clippers:

  • Clippers vs. 76ers spread: 76ers -3
  • Clippers vs. 76ers over-under: 220.5 points
  • Clippers vs. 76ers money line: 76ers -150; Clippers +130
  • LAC: The Clippers are 6-4 against the spread in the last 10 games
  • PHL: The 76ers are 4-6 against the spread in the last 10 games
Featured Game | Philadelphia 76ers vs. Los Angeles Clippers

Why the Clippers can cover

L.A. is leading the NBA in offensive efficiency, illustrating the dynamic nature of its attack. The Clippers are scoring 117.4 points per 100 possessions for the season, and they also lead the league in 3-point shooting (41.8 percent) and free throw shooting (84.1 percent). Tyronn Lue's team lands in the top five in overall field goal percentage (48.5 percent), with only 12.9 turnovers per game, also a top-five mark. 

On the opposite side of the floor, L.A. is also quite effective, with a top-10 overall defense. The Clippers yield fewer than 1.11 points per possession on the whole, with top-four marks in defensive rebound rate (75.6 percent), 3-pointers allowed (11.3 per game), and assists allowed (22.8 per game). The Clippers are a top-10 group in limiting opponent shooting efficiency, headlined by a 3-point percentage allowed of 35.8 percent, and L.A. is above-average in free throw prevention. 

Why the Sixers can cover

Philadelphia is led by Joel Embiid, with the All-NBA center putting together the best season of his career to this point. Embiid is a leading NBA MVP candidate, averaging 29.8 points and 11.0 rebounds per game, and he anchors one of the best defensive teams in the NBA. Embiid is flanked by another standout in Ben Simmons, who is a contender for NBA Defensive Player of the Year honors, and Philadelphia ranks No. 2 in the NBA in defensive rating, allowing only 1.066 points per possession. The 76ers are a top-seven team in the NBA in defensive rebound rate (74.8 percent), turnover creation rate (15.1 percent), shooting efficiency allowed, 2-point shooting allowed (51.0 percent), steals (8.9 per game) and blocks (6.2 per game). 

Offensively, Philadelphia is the No. 1 team in the league in generating free throw attempts, and the Sixers should benefit from a Clippers defense that struggles to create turnovers. The 76ers also have a size edge, and they are a strong offensive rebounding team, grabbing 27.9 percent of their own missed shots this season.

How to make Clippers vs. Sixers picks

SportsLine's model is leaning over on the total, projecting the teams to combine for 212 points. The model also says one side of the spread has all the value. You can get that pick at SportsLine.

So who wins Clippers vs. Sixers? And which side of the spread has all the value? Visit SportsLine now to find out which side of the spread you need to jump on, all from the model that is on a 95-59 roll on NBA picks.