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The Philadelphia 76ers put the best record in the Eastern Conference on the line on Monday evening when they host the Indiana Pacers in a potential playoff preview. Philadelphia is 22-12 overall and dominant at home, posting a 14-3 record at Wells Fargo Center. Indiana is on a three-game losing skid, sliding to 15-17 on the season. Malcolm Brogdon (knee) and Jeremy Lamb (knee) are both questionable for Indiana. Joel Embiid (ankle) and Tobias Harris (knee) are questionable for Philadelphia. 

Tip-off is at 7 p.m. ET in Philadelphia. The latest Sixers vs. Pacers odds from William Hill Sportsbook list Philadelphia as a four-point home favorite. The over-under for total points is set at 223. Before making any Pacers vs. Sixers picks, be sure to see the NBA predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every NBA game 10,000 times, and it returned over $5,000 in profit on its top-rated NBA picks last season. The model also is up almost $8,700 on top-rated NBA picks over the past two-plus seasons. Dating back to last season, it enters Week 10 of the 2020-21 NBA schedule on a stunning 85-49 roll on top-rated NBA picks against the spread. Anybody who has followed it has seen huge returns.

Now, the model has set its sights on 76ers vs. Pacers. You can head to SportsLine to see its picks. Now, here are several NBA odds and betting trends for Pacers vs. 76ers:

  • Pacers vs. 76ers spread: 76ers -4
  • Pacers vs. 76ers over-under: 223 points
  • Pacers vs. 76ers money line: 76ers -165; Pacers +145
  • IND: The Pacers are 3-7 against the spread in the last 10 games
  • PHIL: The 76ers are 4-6 against the spread in the last 10 games

Why the Pacers can cover

The Pacers do have quality options in the frontcourt to help defend Embiid if he's able to go. Domantas Sabonis was named to the All-Star team this year, and he is averaging 21.4 points, 11.4 rebounds and 5.9 assists per game this season. Myles Turner leads the NBA with 3.4 blocked shots per game, and both present size and notable strengths. 

As a team, the Pacers rank in the top 10 in effective field goal percentage allowed (53.0 percent), 2-point shooting allowed (50.9 percent), turnover creation rate (14.9 percent), steals (8.3 per game) and blocks (6.1 per game). Philadelphia is a bottom-five team in taking care of the ball, which could allow the Pacers to create even more havoc. The Pacers also rank in the top seven in offensive turnover rate (13.4 percent) and assists (26.6 per game) so far this season.

Why the 76ers can cover

While Embiid's health status looms large in this matchup, Ben Simmons is also playing some of the best basketball of his career, including 21.0 points per game on 62 percent shooting in February, and he is putting up 16.0 points, 8.1 rebounds and 7.9 assists per game for the season. 

The 76ers have plenty of strengths of their own, but they should also be able to recognize and take advantage of the Pacers' weaknesses. Indiana is a bottom-10 rebounding team on both ends of the floor (24th in overall rebound rate), and the Pacers are below-average in both producing free throw attempts offensively and preventing their opponents from getting to the line.

How to make Pacers vs. Sixers picks

SportsLine's model is leaning under on the total, projecting both teams to combine for 221 points. The model also says one side of the spread hits in over 50 percent of simulations. You can get that pick at SportsLine.

So who wins Pacers vs. Sixers? And which side of the spread hits over 50 percent of the time? Visit SportsLine now to find out which side of the spread you need to jump on, all from the model that on an 85-49 roll on NBA picks.