With the top-seeded Green Bay Packers eliminated, the NFC West steps into the spotlight in the 2022 NFC Championship Game on Sunday. Both the Los Angeles Rams and San Francisco 49ers are 2-0 in the playoffs, with the Rams beating the Cardinals and Buccaneers and the 49ers beating the Cowboys and Packers. Los Angeles hosts the title game at SoFi Stadium, and the Rams are 6-3 at home this season. The 49ers are 8-3 on the road, including playoffs, and San Francisco is 9-2 in its last 11 games.

Kick-off is at 6:30 p.m. ET in Los Angeles. Caesars Sportsbook lists the Rams as 3.5-point home favorites, while the Over-Under, or total number of points Vegas thinks will be scored, is 45.5 in the latest 49ers vs. Rams odds. Before you make any Rams vs. 49ers picks and NFC Championship Game predictions, make sure you check out what SportsLine's resident 49ers expert, Micah Roberts, has to say.

Roberts has worked in the Las Vegas sportsbook industry for 20-plus years, including a 13-year run as Station Casinos' book director. He is 10-6 against the spread in his last 16 NFL picks for a profit of $345. 

In addition, Roberts has gone an astounding 10-1 in his last 11 picks involving San Francisco. Anyone who has followed him is way up.

Now, Roberts has set his sights on 49ers vs. Rams, and just locked in his coveted picks and NFL playoff predictions. You can head to SportsLine now to see his picks. Here are several NFL lines and trends for 49ers vs. Rams:

  • 49ers vs. Rams spread: Rams -3.5 
  • 49ers vs. Rams over-under: 45.5 points 
  • 49ers vs. Rams money line: Rams -175, 49ers +150
  • SF: The 49ers are 9-2 against the spread in their last 11 games 
  • LAR: The Rams are 6-2 against the spread in their last eight games
Featured Game | Los Angeles Rams vs. San Francisco 49ers

Why the 49ers can cover

San Francisco is rightfully known for its defense, but the offense has been quietly prolific this season. The 49ers scored 25.1 points per game in the regular season, an above-average mark, and San Francisco finished No. 7 in the NFL in total offense (375.7 yards per game). The 49ers are above-average in passing offense with almost 250 yards per game, and San Francisco allowed only 33 sacks this season. That pass protection is key against Los Angeles, and the 49ers are No. 2 in the NFL in averaging 8.6 yards per pass attempt. 

San Francisco is also quite good on the ground, averaging 127.4 yards per game on the ground to rank No. 7 in the NFL. The Rams are talented on defense, but Los Angeles is strongly below the league average in first downs allowed, passing yards allowed, rushing touchdowns allowed and third down efficiency allowed this season.

Why the Rams can cover

The Rams are very good on defense, headlined by 50 regular season sacks and various top-10 marks in the NFL. Los Angeles also has a favorable matchup against a sometimes shaky 49ers offense, but the Rams still rely on a potent offense. Los Angeles scored 27.1 points per game this season, ranking in the top eight of the NFL, and the Rams scored on nearly 46 percent of possessions. Los Angeles averaged 2.50 points per drive, and the Rams ranked in the top 10 in regular season total offense (372.1 yards per game) and yards per drive (34.9). 

The Rams kept the chains moving, converting 43.9 percent of third downs and ranking No. 7 in the NFL. Los Angeles was also above-average in red zone offense, scoring a touchdown on 60.0 percent of trips inside the 20-yard line, and the Rams are above-average in first downs, fumble avoidance, sack avoidance and passer rating. 

How to make 49ers vs. Rams picks

Roberts has analyzed this matchup and while we can tell you he's leaning under on the point total, he has also discovered a critical X-factor that has him jumping all over one side of the spread. He's only sharing what it is, and which side of the Rams vs. 49ers spread to back, at SportsLine.

So who wins 49ers vs. Rams in the NFL playoffs 2022? And what critical X-factor makes one side of the spread a must-back? Visit SportsLine now to see Roberts' Rams vs. 49ers picks, all from the NFL expert who's an amazing 10-1 on picks involving San Francisco, and find out.