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The well-rested Green Bay Packers will host the San Francisco 49ers in the 2022 NFL playoffs on Saturday at Lambeau Field. Green Bay earned a bye week as the No. 1 seed in the NFL playoff bracket and is 13-4 this season. Green Bay is also 8-0 at home and won a Week 3 matchup in San Francisco. The 49ers are 11-7 including the NFL playoffs, but San Francisco is also 7-3 in road environments, headlined by a win over the Dallas Cowboys last week.

Kickoff is at 8:15 p.m. ET in Green Bay. Caesars Sportsbook lists the Packers as 5.5-point home favorites, while the Over-Under, or total number of points Vegas thinks will be scored, is 47.5 in the latest Packers vs. 49ers odds. Before you make any 49ers vs. Packers picks and NFL playoff predictions, make sure you check out what SportsLine NFL expert R.J. White has to say.

CBS Sports' Fantasy and gambling editor, White ended the 2020 season on an 80-59 run on all NFL picks, returning more than $1,400 during that span. It's no surprise, as White has cashed huge twice in the world's most prestigious football handicapping competition, the Las Vegas SuperContest.

In addition, White has gone an astounding 50-16-1 on his last 67 picks involving Green Bay, returning more than $3,100. Anyone who has followed him is way up.

Now, White has set his sights on 49ers vs. Packers, and just locked in his coveted picks and NFL playoff predictions. You can head to SportsLine to see White's picks. Now, here are several NFL playoff odds and divisional round betting lines for 49ers vs. Packers:

  • Packers vs. 49ers spread: Packers -5.5
  • Packers vs. 49ers over-under: 47.5 points 
  • Packers vs. 49ers money line: Packers -240, 49ers +200 
  • SF: 49ers are 5-1 against the spread in their last six games 
  • GB: Packers are 12-5 against the spread this season
Featured Game | Green Bay Packers vs. San Francisco 49ers

Why the 49ers can cover

San Francisco was fourth in the NFL in rushing during the regular season, gaining an average of 127.4 yards per game. Elijah Mitchell led the team and ranked eighth in the league with 963 yards despite missing six contests. The 23-year-old rookie posted five 100-yard performances and nearly recorded another in his postseason debut as he ran for 96 yards and a touchdown in last Sunday's 23-17 triumph against the Cowboys.

Another threat on the ground is Deebo Samuel, who carried 10 times for 72 yards and a TD versus Dallas. The 26-year-old gained the most rushing yards in a game by a wide receiver in NFL playoff history, overtaking James Lofton (71 against Dallas in 1983) for the record. Samuel, who led the 49ers during the regular season with career-highs of 77 catches and 1,405 receiving yards, was second on the team in rushing with 365 yards and has averaged 6.6 per carry while producing eight touchdown runs over his last nine contests.

Why the Packers can cover

San Francisco's defense is strong, but if the 49ers have a weakness, it is with havoc-creation on the backend. The 49ers have only nine interceptions this season, landing in the bottom 10 of the NFL, and Green Bay is poised to take advantage of that shortcoming. The Packers have committed the fewest turnovers (13) in the NFL this season, giving the ball away on 6.4 percent of possessions, and only thrown seven interceptions this season.

Green Bay also scores at a high level, putting up 26.5 points per game and 2.54 points per drive while producing points on 44.5 percent of offensive possessions. The Packers are also in the top five in yardage efficiency, generating 35.9 yards per drive, and in the top eight in first downs (375), passing yards (4,315), passing touchdowns (39) and completion rate (67.8 percent).

How to make 49ers vs. Packers picks

White has analyzed this matchup and while we can tell you he's leaning under on the point total, he has also discovered a critical X-factor that has him jumping all over one side of the spread. He's only sharing what it is, and which side of the Packers vs. 49ers spread to back, at SportsLine.

So who wins 49ers vs. Packers in the NFL playoffs 2022? And what critical X-factor makes one side of the Packers vs. 49ers spread a must-back? Visit SportsLine now to see White's 49ers vs. Packers picks, all from the NFL expert who's 50-16 on picks involving Green Bay, and find out.