The Jacksonville Jaguars will take on the San Francisco 49ers at 1 p.m. ET on Sunday at TIAA Bank Field. The Jaguars are 2-7 overall and 2-3 at home, while San Francisco is 4-5 overall and 3-1 on the road. The Niners have won two of their last three games. The Jags have lost two of their last three games.
The 49ers have won the last three games between the teams. San Francisco is favored by 6.5 points in the latest Jaguars vs. 49ers odds from Caesars Sportsbook, and the over-under is set at 45. Before entering any 49ers vs. Jaguars picks, you'll want to see the NFL predictions from the model at SportsLine.
The model, which simulates every NFL game 10,000 times, is up almost $7,500 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 11 of the 2021 season on an incredible 128-89 run on top-rated NFL picks that dates back to the 2017 season.
The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.
Now, the model has set its sights on Jaguars vs. 49ers. You can head to SportsLine to see its picks. Here are several NFL betting lines for Niners vs. Jags:
- Jaguars vs. 49ers spread: 49ers -6.5
- Jaguars vs. 49ers over-under: 45 points
What you need to know about the Jaguars
Jacksonville lost 23-17 to the Indianapolis Colts this past Sunday. It was the 12th consecutive road loss for the Jaguars. Jacksonville overcame an early 17-0 deficit but could not complete the comeback. Jamal Agnew rushed for a 66-yard TD/
Trevor Lawrence was 3 of 14 with 56 yards in the first half in Week 10. He finished 16 of 35 with 162 yards. James Robinson (heel/knee) is questionable for Sunday's game.
What you need to know about the 49ers
Meanwhile, San Francisco made easy work of the Los Angeles Rams in a 31-10 upset victory. Deebo Samuel punched in a rushing touchdown in addition to catching five passes for 97 yards and a TD. He is second in the NFL with 979 receiving yards. That is the second-most in franchise history in the first nine games of the season, behind only Jerry Rice's 1,006 in 1990.
George Kittle had his second receiving TD of the season last week. Elijah Mitchell (finger) is doubtful for Week 11.
How to make 49ers vs. Jaguars picks
The model is leaning under on the total, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the pick at SportsLine.
So who wins Jaguars vs. 49ers? And which side of the spread hits well over 50 percent of the time? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks.
