The Los Angeles Rams look to keep the heat on the NFC West contenders when they battle the San Francisco 49ers on Sunday Night Football. The Rams (4-1) enter the weekend one game behind the first-place Seattle Seahawks and one game ahead of the Arizona Cardinals. The 49ers (2-3), meanwhile, need to pick up a win to remain within striking distance of the division leaders. San Francisco has won six of the past nine games in the series with Los Angeles.

The game from Levi's Stadium in Santa Clara, Calif., is slated to start at 8:20 p.m. ET. The Rams are favored by 2.5-points in the latest Rams vs. 49ers odds from William Hill, while the over-under for total points scored is 51.5. Before making any 49ers vs. Rams picks, check out the NFL predictions from the SportsLine Projection Model

The model, which simulates every NFL game 10,000 times, is up over $7,500 for $100 players on top-rated NFL picks since its inception five-plus years ago. It's off to a strong 10-5 roll on top-rated NFL picks this season. The model enters Week 6 on an incredible 106-70 run on top-rated NFL picks that dates back to the 2017 season. 

The model ranked in the Top 10 on NFLPickWatch in three of the past four years on straight-up NFL picks and beat more than 95 percent of CBS Sports office pool players three times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on 49ers vs. Rams. You can visit SportsLine now to see the picks. Here are the NFL lines and trends for Rams vs. 49ers:

  • 49ers vs. Rams spread: Rams -2.5
  • 49ers vs. Rams over-under: 51.5 points
  • 49ers vs. Rams money line: Rams -135, 49ers +115
  • LAR: Seventh in rushing yards per game (142.3)
  • SF: Over has hit in three Niners games this season

Why the Rams can cover

Los Angeles' offense is led by quarterback Jared Goff, who has played well against the 49ers in the past. In seven career starts at San Francisco, Goff has passed for 817 yards with seven touchdowns and one interception for a 113.4 rating. In three road games this year, Goff has completed 64-of-89 passes for 897 yards and seven touchdowns. For his career, he has completed 63 percent of his passes for 15,591 yards and 95 touchdowns.

Besides leading rusher Darrell Henderson Jr., the Rams have also gotten a lot of production from running backs Malcolm Brown and Cam Akers. Brown has carried 53 times for 213 yards (4.0 average) and two touchdowns. He has also converted 16 first downs. Akers, who rushed for a career-high 61 yards last week, has carried 26 times for 113 yards (4.3 average) with two first-down conversions.

Why the 49ers can cover

Tight end George Kittle returned to action last week and gives the San Francisco offense another weapon. Despite playing in just three of the 49ers' five games, Kittle leads the team with 23 receptions for 271 yards and one touchdown. In three career games on Sunday Night Football, Kittle has 28 receptions for 398 yards (132.7 per game) and two receiving TDs. He had 79 receiving yards and a touchdown catch in the last meeting with Los Angeles, and has 31 receptions for 529 yards and three touchdowns in his past five games against the Rams.

Also powering the 49ers is wide receiver Deebo Samuel, who played for the second week in a row last Sunday against the Dolphins after missing the first three weeks of the season with a foot injury and an illness. Samuel has five receptions for 54 yards, including four first-down conversions. In his last meeting against the Rams, Samuel had a rushing TD. In three career Sunday Night Football games, he has 230 yards from scrimmage and two touchdowns, including one receiving.

How to make 49ers vs. Rams picks

SportsLine's model is leaning under on the total. In fact, it says Goff will pass for fewer than 275 yards and two touchdowns, while Jimmy Garoppolo will throw for 225 yards and one TD. It has also generated an against-the-spread pick that cashes in well over 50 percent of simulations. You can only get the pick here

So who wins Rams vs. 49ers on Sunday Night Football? And which side of the spread cashes in well over 50 percent of simulations? Visit SportsLine now to see which side of the Rams vs. 49ers spread to jump on, all from the advanced model that is up well over $7,500 on its NFL picks, and find out.