Week 16 of a spellbinding 2021 NFL schedule will begin with 49ers vs. Titans on Thursday Night Football. Both teams would qualify for the NFL playoffs if they began today, but both squads will have to hold off several other challengers in the most crowded postseason race in NFL history. The Titans are hoping that wide receiver A.J. Brown will be able to return to action after suffering a chest injury, but what can you expect from the star receiver as you look at the latest NFL player props?

49ers wide receiver Deebo Samuel has scored a rushing touchdown in five consecutive weeks, and Caesars Sportsbook lists him at +103 to score any time and +600 to be the first touchdown scorer in its Thursday Night Football NFL props. Are either of those NFL prop bets worth your consideration, and what other 49ers vs. Titans props should be on your radar? Before making any NFL prop bets for Thursday Night Football, you need to see the Titans vs. 49ers prop predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up over $7,000 for $100 players on top-rated NFL picks since its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 16 of the 2021 season on an incredible 133-96 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

It can also be used to crush NFL prop picks. Last season, its NFL prop bets went 389-310, returning over $3,000.

With 49ers vs. Titans on Thursday Night Football approaching, the model has evaluated the NFL player props from Caesars and found five strong bets. You can only see them here.

Top NFL player prop bets for 49ers vs. Titans

After simulating Titans vs. 49ers 10,000 times, the model predicts that 49ers quarterback Jimmy Garoppolo goes over 236.5 passing yards. Despite looking like a candidate to lose his job early in the season after the 49ers drafted Trey Lance, Garoppolo has held on to his job and San Francisco's offense has looked formidable under his leadership.

Garoppolo currently leads the NFL in yards per pass attempt (8.5) and Garoppolo has been poised and accurate, particularly under duress. Garoppolo ranks third in the NFL in pressured completion percentage (56.4) and has thrown for at least 295 yards in two of his last three starts. The model predicts he'll throw for 257 yards on average against a Titans defense that ranks 20th against the pass.

SportsLine's NFL model also says 49ers wide receiver George Kittle goes over 68.5 total receiving yards. Since the calendar changed to December, Kittle has caught 28 passes for 425 yards and three touchdowns. Despite missing three games, Kittle is second among NFL tight ends in yards after the catch (424) and third in receiving yards (850). Garoppolo likes to get Kittle involved early, with five of his 12 catches of 20 or more yards coming in the first quarter, so look for Kittle to eat up a chunk of that total early and finish with 81 yards on average.

How to make NFL player prop bets for Titans vs. 49ers

In addition, the model says another star easily surpasses his yardage total and has another plus-money prop payout you'll want to jump on. You need to see the model's analysis before making any 49ers vs. Titans prop bets for Thursday Night Football.

Which 49ers vs. Titans prop bets should you target on Thursday Night Football? And which plus-money prop is a must-back? Visit SportsLine now to see the top Titans vs. 49ers prop bets, all from the model that's up over $7,000 on top-rated NFL picks.