The 2025 NFL season is here and Sunday has the first full slate of the year with 13 games on Sept. 7. From key divisional matchups to a massive playoff rematch, we've got a little bit of everything in Week 1. Two of those divisional showdowns are part of our Caesars Sportsbook three-leg parlay for Sunday.
NFL Week 1 parlay (odds via Caesars)
Rams money line vs. Texans (-160)
Packers money line vs. Lions (-135)
Seahawks money line vs. 49ers (+115)
Final odds: +508 (wager $100 to win $508)
Rams (-160) vs. Texans
Matthew Stafford's health has been a question mark all offseason as the longtime veteran quarterback has been banged up with a back injury. He's off the injury report for Sunday, though, and will have a new weapon to play with in Week 1 as the Rams signed Davante Adams and his 103 career touchdowns to replace Cooper Kupp. This should give Stafford a big red zone target while also freeing up Puka Nacua with better matchups. The Texans are fresh off consecutive 10-7 seasons and back to back AFC South titles, but vibes seem down for Houston. The team appears to have lost momentum last year due largely to a sophomore slump from C.J. Stroud, and the run game will take a hit early with Joe Mixon is out for at least the first four games. Additionally, receiver Tank Dell is likely to miss the whole season, and new receiver Christian Kirk will miss at least this Week 1 matchup. Those are three big pieces to be without on offense against a tough Los Angeles defense that really found a groove late last year. The Rams should be able to handle the Texans at home in Week 1. The SportsLine model backs the Rams on the money line, as they win in 60% of simulations.
Packers (-135) vs. Lions
Packers fans have been waiting for this game for a long time. The Lions were the talk of the NFL a year ago, going 15-2 behind one of the best scoring offenses in league history before crashing out in the Divisional Round. Detroit lost both its coordinators in the offseason, but Dan Campbell, Jared Goff and most of the skill players are back. The Packers made a big swing trading for Micah Parsons, and he should be good to go for this contest. Green Bay is finally getting a home game to open the season, and the Packers have generally played the Lions well, but that usually happens in the second game of the year. There should be some regression for Detroit, and with Parsons adding another element to this aggressive Green Bay defense, I think we see the Packers start the season 1-0. Green Bay wins in 62% of simulations in the SportsLine Projection Model.
Seahawks (+115) vs. 49ers
The SportsLine Projection Model likes the Seahawks in this one, as Seattle wins in 58% of simulations, good for an 'A' grade. Mike Macdonald enters Year 2 as head coach and he has a new-look offense, namely at quarterback with Sam Darnold now in Seattle passing to a reshuffled its wide receiver room. Nonetheless, the model likes the Seahawks at home against a 49ers team that again faces injury questions as Christian McCaffrey is questionable and Brandon Aiyuk is out to begin the year, which means a lot of the receiving work will fall on Jauan Jennings, George Kittle and Ricky Pearsall. Brock Purdy got paid a huge contract in the offseason, and this will be an early test to see if he's ready to step up as an elite quarterback. The model says otherwise, and I'll roll with the Seahawks as a home underdog in what is always one of the toughest environments for visiting teams.
