Watkins will miss a minimum of eight weeks as a result of the injury, but it could amount to the young receiver missing the rest of the season.
Back in May, the talented third-year wide receiver suffered a foot injury and underwent surgery. It was a similar injury to what Julio Jones and Dez Bryant dealt with in the last couple of seasons, a Jones fracture, leading many to believe the injury could be more significant than a simple several-week recovery.
Rex Ryan admitted early Friday that Watkins' injury was a major concern for the duration of the season, and that concern quickly came to fruition.
CBSSports.com senior Fantasy writer Jamey Eisenberg advocates dropping Watkins in the majority of Fantasy leagues and lists the best possible roster replacements for the injured receiver.
Watkins is a transcendent receiver when he's healthy, but the decision by Buffalo to trade a future first-round pick in order to acquire Watkins doesn't look fantastic at this point (Odell Beckham, Jr., was taken several picks after the Bills' pre-trade first-round pick).
The bigger issue here is the Bills having a public battle with Watkins over whether or not he's healthy enough to play through the pain. The Jones fracture doesn't work like that -- you have to let the bone heal and you have to reasonably understand that it's just not going to be a simple several-week issue.
Now the Bills are facing a situation where their top defensive player -- Marcell Dareus -- is suspended and sitting on a weighty contract, and their top offensive player -- Watkins -- is likely to miss the year.
With Rex's back against the wall, things couldn't be worse for Buffalo in terms of trying to win games.