After losing in the AFC Championship Game, the Buffalo Bills appear to be on a mission in 2021, and one critical step on the way to proving themselves will be redeeming a 42-16 loss to the Tennessee Titans last season during a coronavirus makeup game on a Tuesday in early October. They'll get that chance on Monday Night Football in Week 6 when the Bills (4-1) visit Nissan Stadium to take on the 3-2 Titans. Buffalo is a six-point favorite in the latest NFL odds from Caesars Sportsbook, but in addition to the spread, there are plenty of NFL player props.

Buffalo outgained Tennessee in that game 370-334 but was undone by three turnovers. Quarterback Josh Allen threw two interceptions, and the latest Bills vs. Titans props from Caesars Sportsbook list Allen at +110 to throw an interception this time around. Will a struggling Titans secondary be able to surprise Allen again or should you explore other NFL prop bets? Before making any NFL player props for Monday Night Football, you need to see the Bills vs. Titans prop predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 6 of the 2021 season on an incredible 125-83 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

It can also be used to crush NFL prop picks. Last season, the player over-under prop picks went 389-310, returning over $3,000.

With Titans vs. Bills on Monday Night Football, the model has evaluated the NFL player props from Caesars and found five strong bets. You can only see them here.

Top NFL player prop bets for Bills vs. Titans

After simulating Titans vs. Bills 10,000 times, the model predicts that Titans running back Derrick Henry will surpass 98.5 rushing yards and finish with 110. Henry had a surprisingly tough start to his season, rushing for just 58 yards on 17 carries in a loss to the Cardinals.

But it's been business as usual in the four weeks since, as he's rushed 125 times for 582 yards and seven touchdowns while also catching 11 passes for 106 yards. Henry has topped 98 yards in 14 of his last 21 games, and with the Titans passing for less than 200 yards in three of their five games this season, they're likely to stay committed to the run regardless of game flow.

SportsLine's NFL model also says Bills quarterback Josh Allen will top 292.5 passing yards. Like Henry, Allen began his season relatively slowly, averaging just 5.3 yards per pass attempt in his first two games after averaging 7.9 a year ago.

However, he's caught fire the last three weeks, completing 67-of-99 passes for 921 yards and nine touchdowns with just one interception. Now, he'll take on a Titans defense that ranks 21st in pass defense and that ranked 29th a season ago. The model is projecting that Allen will throw for 298 yards on Monday Night Football.

How to make NFL player prop bets for Titans vs. Bills

In addition, the model says another star easily surpasses his yardage total and has a plus-money prop payout you'll want to jump on. You need to see the model's analysis before making any Titans vs. Bills prop bets.

Which Bills vs. Titans prop bets should you back on Monday Night Football? And which star smashes his total? Visit SportsLine now to see the top Bills vs. Titans prop bets, all from the model that's up almost $7,900 on top-rated NFL picks.