Browns vs. Colts odds, predictions: 2019 Preseason Week 2 NFL picks from expert on 63-46 roll

The Cleveland Browns seek their second win of the 2019 NFL preseason when they visit the Indianapolis Colts on Saturday. Kickoff is scheduled for 4 p.m. ET from Lucas Oil Stadium. The Browns are favored by oddsmakers to win the AFC North following a 7-9 season in which Baker Mayfield emerged as their long-coveted franchise quarterback. He threw a touchdown pass on his only series of their 30-10 win over the Washington Redskins in their preseason opener. The Colts are looking for their first preseason win and hope to make progress amid the uncertainty of quarterback Andrew Luck, who is sidelined indefinitely with an ankle injury. They fell 24-16 to the Buffalo Bills in their exhibition opener. Indianapolis is a 3-point favorite and the over-under for total points scored is 43 in the latest Browns vs. Colts odds. Before you finalize your Browns vs. Colts picks, check out the NFL predictions from SportsLine analyst Mike Tierney.

Tierney has been a winner for SportsLine members in every sport, but the NFL is his specialty. An acclaimed sportswriter whose work appears in the New York Times and Los Angeles Times, Tierney has reported from seven Super Bowls. Tierney was all over the New England Patriots covering against the Los Angeles Rams in the Super Bowl, enabling him to finish last season with a sparkling 63-46 record against the spread.

What's more, Tierney's analytical expertise already has paid dividends in the 2019 NFL preseason. He advised SportsLine members that he expected Arizona Cardinals rookie quarterback Kyler Murray to struggle when he saw extensive action on Thursday against the Oakland Raiders. The result: Murray went 3-for-8 passing for 12 yards, took two sacks and committed two false-start penalties in Arizona's 33-26 loss. Anyone who followed Tierney's advice booked another easy winner, and those who have consistently followed him are way, way up.

Now, Tierney has evaluated Browns vs. Colts from every angle and locked in a strong point-spread pick. He's only sharing it over at SportsLine.

Tierney knows the Colts will be eager to show improvement, especially because of the uncertainty with Luck. Luck's injury was first thought to be minor, but he is now sidelined indefinitely and coach Frank Reich told the media it's unclear whether he will be available for their Sept. 8 season-opener against the Los Angeles Chargers.

This means extra work and preparation will come for backup Jacoby Brissett, who has been in this position before. He started 15 games for the Colts in 2017 while Luck was shelved with a shoulder injury and threw for 3,098 yards and 13 touchdowns against seven interceptions. Brissett went 2-for-5 for 21 yards in three series in the preseason opener. Chad Kelly stepped in and impressively went 13-for-19 for 121 yards. Kelly also was the team's leading rusher with 53 yards on four carries and a touchdown.

Even so, there's no guarantee that Indianapolis will cover the Colts vs. Browns spread against a Cleveland team that has shown over the past two years it takes a serious approach to preseason contests.

The Browns were effective on offense despite the absence of high-profile acquisition Odell Beckham Jr., who is nursing a hip injury. First-year coach Freddie Kitchens told the media it was likely Beckham would be rested again Saturday. But both the coach and receiver said they expect the player will be ready for the team's regular-season opener.

Fellow receiver Jarvis Landry also sat out the exhibition opener for rest and it's unclear whether he will play Saturday. But the absences of the two receivers allowed the Browns to build depth at the position, and the preseason opener showed positive returns. Seven players had at least two receptions, led by Rashard Higgins with five catches for 98 yards and a touchdown. 

We can tell you Tierney is leaning under, but his much stronger play is on the spread. Tierney has unearthed a critical X-factor that has him going big on one side. He's only sharing what it is, and who to back, at SportsLine.

So who wins Browns vs. Colts? And what critical X-factor makes one side of the spread a must-back? Visit SportsLine now to see which side of the Browns vs. Colts spread you should jump on Saturday, all from the seasoned expert who went 63-46 against the spread last season.

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