The Jacksonville Jaguars will take on the Cleveland Browns at 1 p.m. ET on Sunday at TIAA Bank Field. Jacksonville is 1-9 overall and 1-4 at home, while Cleveland is 7-3 overall and 2-2 on the road. The Browns have won three of their past four games. The Jaguars have not won since their season opener. 

Cleveland is favored by seven points in the latest Jaguars vs. Browns odds from William Hill Sportsbook, and the over-under is set at 49.5. Before making any Browns vs. Jaguars picks, you'll want to see the NFL predictions from the model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up more than $7,800 for $100 players on top-rated NFL picks since its inception five-plus years ago. It is a sizzling 19-10 on top-rated NFL picks this season, returning almost $800. The model also enters Week 12 on an incredible 115-75 run on top-rated NFL picks that dates back to the 2017 season. 

The model ranked in the Top 10 on NFLPickWatch three of the past four years on straight-up NFL picks and beat more than 95 percent of CBS Sports office pool players three times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Jaguars vs. Browns. You can head to SportsLine to see its picks. Here are several NFL betting lines for Browns vs. Jaguars:

  • Jaguars vs. Browns spread: Jaguars +7
  • Jaguars vs. Browns over-under: 49.5 points
  • Jaguars vs. Browns money line: Jacksonville +260, Cleveland -320

What you need to know about the Jaguars

The Jaguars took a 27-3 loss to the Pittsburgh Steelers this past Sunday. Jake Luton threw four interceptions with only 151 yards passing and he had no TD passes. Jacksonville tied a franchise record with its ninth consecutive loss. The Jaguars are now 41-100 in owner Shad Khan's nine-year tenure. He tied former Saints owner John Mecom Jr. as the second fastest to reach 100 losses.  Defensive end Josh Allen suffered a knee injury in the loss and was placed on injured reserve.  

Wide receivers D.J. Chark (ribs) and Chris Conley (hip) are out for Week 12. Laviska Shenault Jr. has missed two games with a hamstring injury but is not on the injury report. Guard Andrew Norwell (arm) is also out with an arm injury. Mike Glennon will take over as the starting quarterback for Jacksonville this week, as he gets his first start since 2017. He has a 6-16 career record. James Robinson leads rookies in scrimmage yards (1,011) and rushing yards (762) and is the fifth undrafted rookie with 1,000-plus scrimmage yards in the common-draft era.

What you need to know about the Browns

Meanwhile, the Browns beat the Philadelphia Eagles 22-17 this past Sunday. Cleveland's 7-3 record at this point is its best since the 1994 season. Nick Chubb rushed for team-high 114 yards last week and he has went over 100 yards in each of his past two games. Kareem Hunt has 70-plus scrimmage yards in three of his past four games. Hunt (644) and Chubb (575) are the only pair of running back teammates to have gone over 500 rushing yards this season. 

Baker Mayfield passed for 204 yards last week. He has not thrown an interception in his past three games. Mayfield has two-plus TD passes in two of his past three road games. Olivier Vernon tied a career high with three sacks and registered his first career safety last week. He has five sacks in his past three games. Adrian Clayborn had a career-high 1.5 sacks vs. Philadelphia. The Browns have lost four of their past five meetings with the Jaguars and 12 of 17 in the all-time series. Myles Garrett (reserve/COVID-19 designation) will miss his second consecutive game. 

How to make Jaguars vs. Browns picks

The model has simulated Jaguars vs. Browns 10,000 times and the results are in. It is leaning under on the total, and it's also generated a point-spread pick that is hitting in over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Jaguars vs. Browns? And which side of the spread hits in over 50 percent of simulations? Visit SportsLine now to see which side of the Browns vs. Jaguars spread to jump on Sunday, all from the model that enters Week 12 of the NFL season on an incredible 115-75 roll.