Tom Brady and the Tampa Bay Buccaneers will try to overpower the Philadelphia Eagles on Thursday Night Football, but the Week 6 NFL matchup won't be easy. The Bucs (4-1) come in with the NFL's best passing offense, but the Eagles (2-3) rank third in defending it. Eagles quarterback Jalen Hurts faces a Tampa Bay defense that is the league's worst against the pass. The NFC inter-division matchup could turn into a chess match, and the Lincoln Financial Field crowd certainly won't take it easy on Brady. The Eagles are on a roll in Thursday night games, but the Bucs have won three of the last four meetings between the teams in Philadelphia.

Kickoff from Lincoln Financial Field is set for 8:20 p.m. ET. Tampa Bay is a seven-point favorite in the latest Buccaneers vs. Eagles odds from Caesars Sportsbook, while the Over-Under is 52.5. Before locking in any Buccaneers vs. Eagles picks, make sure you check out the NFL predictions and analysis from the proven SportsLine Projection Model

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 6 of the 2021 season on an incredible 125-83 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has simulated Buccaneers vs. Eagles 10,000 times and just revealed its NFL picks and predictions. You can head to SportsLine now to see its picks. Here are several NFL odds and betting lines for Eagles vs. Buccaneers:

  • Buccaneers vs. Eagles spread: Tampa Bay -7 
  • Buccaneers vs. Eagles over-under: 52.5 points 
  • Buccaneers vs. Eagles money line: Tampa Bay -320, Philadelphia +250 
  • TB: Over is 6-1 in Buccaneers' last seven games as favorites  
  • PHI: Eagles are 4-0 against the spread in their last four home games  
Featured Game | Philadelphia Eagles vs. Tampa Bay Buccaneers

Why the Buccaneers can cover

Tampa Bay is 14-11 against the spread since Brady took over last season. The seven-time Super Bowl champion comes off the first game of his storied career in which he had more than 400 passing yards and five TDs. He threw for 411 yards to give him a league-best 1,767 this season and ranks second in the NFL with 15 TD passes while throwing two interceptions. He has what might be the NFL's best trio of receivers, with Mike Evans, Chris Godwin and Antonio Brown teaming up for 78 receptions (19 longer than 20 yards) and nine touchdowns.

Tampa Bay averages just 82 rushing yards per game, but the backs are heavily involved in the passing game. Leonard Fournette (19 receptions, 4.5 yards per rush) and Giovani Bernard (16, 5.3) are dangerous receivers but can run when they need to. The Eagles rank 30th in the league against the run (142 yards per game), so they could see more handoffs this week.

Why Eagles can cover 

Jalen Hurts and the Eagles rolled into Bank of America Stadium last Sunday and beat the Carolina Panthers in Week 5. Philadelphia's defense came to play on Sunday and caused havoc for Sam Darnold. The Eagles snagged three interceptions on the day and held Darnold to 177 passing yards. The Eagles' offense struggled in the first half, but found its groove after the break. 

Hurts connected with receiver Quez Watkins for a 53-yard gain to put Philadelphia in the red zone. Hurts then forced his way into the end zone for a rushing touchdown. The 2020 second-round pick rushed for two scores and led the Eagles to 15 second-half points. Philadelphia showed its grit and desire in its comeback victory against Carolina and will carry that momentum on a short week against the Bucs.

How to make Buccaneers vs. Eagles picks 

SportsLine's model is leaning under on the point total, projecting the teams to combine for 50 points. It also says one side of the Eagles vs. Buccaneers spread has all the value. You can only see the model's Buccaneers vs. Eagles picks at SportsLine.

So who wins Buccaneers vs. Eagles on Thursday Night Football? And which side of the spread has all the value? Visit SportsLine now to see which side of the Buccaneers vs. Eagles spread to jump on, all from the advanced model that is up over $7,900 on its NFL picks, and find out.