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The Carolina Panthers and the Tampa Bay Buccaneers will face off in a NFC South clash at 1 p.m. ET on Sunday at Bank of America Stadium. Carolina is 3-6 overall and 1-3 at home, while Tampa Bay is 6-3 overall and 3-2 on the road. The Buccaneers won the first meeting this season, 31-17 in Week 2. 

Tampa Bay is favored by six points in the latest Panthers vs. Buccaneers odds from William Hill Sportsbook. The over-under is set at 50.5 points. Before finalizing any Buccaneers vs. Panthers picks, you'll want to see the NFL predictions from the model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up over $7,600 for $100 players on top-rated NFL picks since its inception five-plus years ago. It's off to a strong 16-9 roll on top-rated NFL picks this season. The model also enters Week 10 on an incredible 112-74 run on top-rated NFL picks that dates back to the 2017 season. 

The model ranked in the Top 10 on NFLPickWatch three of the past four years on straight-up NFL picks and beat more than 95 percent of CBS Sports office pool players three times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Panthers vs. Bucs. You can head to SportsLine to see its picks. Here are several NFL betting lines for Bucs vs. Panthers:

  • Panthers vs. Buccaneers spread: Panthers +6
  • Panthers vs. Buccaneers over-under: 50.5 points
  • Panthers vs. Buccaneers money line: Carolina +210, Tampa Bay -250

What you need to know about the Panthers

The Panthers were edged by the Kansas City Chiefs this past Sunday, 33-31. It was Carolina's fourth consecutive loss. Christian McCaffrey punched in one rushing touchdown in addition to catching 10 passes for one TD and 82 yards, but suffered a shoulder injury and will not play in Week 10. Mike Davis had eight receptions for 74 yards in the Week 2 meeting. He ranks second among running backs with 43 catches this season.

Robby Anderson had nine receptions for 63 yards last week. He had nine catches for 109 yards in the Week 2 meeting. Anderson is one of two wide receivers with eight games of five-plus catches this season. Curtis Samuel set career-highs in catches (nine) and receiving yards (105) and had a receiving TD last week. He has a TD in three consecutive games. The Panthers have lost three of their past four meetings with the Buccaneers. 

What you need to know about the Buccaneers

Meanwhile, Tampa Bay entered its matchup against the New Orleans Saints this past Sunday without any home losses but were trampled in a 38-3 defeat. The Bucs were down 31-0 at the end of the third quarter. They had five rushing attempts, which set the NFL record for fewest rushing attempts in a game. The loss ended a three-game winning streak for Tampa Bay and was the worst defeat of Tom Brady's career. He threw three interceptions and was sacked three times. 

Leonard Fournette and Ronald Jones combined for three rushing TDs in the Week 2 meeting, Mike Evans had 104 yards and a TD in that game. Chris Godwin has reached 100 yards in his last three meetings with the Panthers. Antonio Brown caught three passes for 31 yards in his Tampa Bay debut in Week 9. Devin White had a career-high 15 tackles in the Week 2 meeting with Carolina. 

How to make Buccaneers vs. Panthers picks

SportsLine's model has simulated Panthers vs. Buccaneers 10,000 times and the results are in. The model is leaning over on the total, and it's also generated a point-spread pick that is hitting in over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Panthers vs. Buccaneers? And which side of the spread hits in over 50 percent of simulations? Visit SportsLine now to see which side of the Panthers vs. Buccaneers spread to jump on Sunday, all from the model that enters Week 10 of the NFL season on an incredible 112-74 roll.